Also known as: Monochloroacetic acid, UN 1750 (DOT), 2-Chloroacetic acid, α-Chloroacetic acid, UN 1751 (DOT) (+14 more)
CAS 79-11-8
Chloroacetic acid (CAS 79-11-8) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H311; H301; H314; H400. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Chloroacetic acid is prohibited in EU cosmetics but has active industrial GHS classifications (H331, H311, H301, H314, H400).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B; Aquatic Acute 1 | H331; H311; H301; H314; H400 | GHS06; GHS05; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | May be osive to metals Toxic if swallowed or in contact with skin Causes severe skin burns and eye damage May cause respiratory irritation Causes damage to organs Very toxic to aquatic life |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. See Notes. The substance may cause effects on the metabolism. This may result in metabolic acidosis and multiple organ failure. Exposure could cause death. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged inhalation may cause effects on the lungs. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| ACGIH | TWA | 0.5 ppm (inhalable fraction and vapor) [2005] | 0.5 | - | Y |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8.5 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| =2 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 5GD84Y125G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5GD84Y125G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5GD84Y125G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5GD84Y125G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.18 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 0.1808 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >0.225 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >1268 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =55 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =76 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =90 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =309171 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =19 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =30 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =3.5 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =7.04 | mg/L | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =14.07 | mg/L | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =15 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~25 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| >=28.15 | mg/L | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =120 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =193 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=30 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=59.9 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=80 | mg/kg bw/day | NOEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| >=100 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =0.002 | mg/kg bw/day | RfD | oral | Human | ToxValDB_Pennsylvania_DEP_ToxValues |
| =0.0035 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =0.01 | mg/kg bw/day | RfD | oral | Human | ToxValDB_OW_Drinking_Water_Standards |
| 30 | mg/kg | Top dose | Gavage | Rat | NTP_ICE_cancer |
| 100 | mg/kg | Top dose | Gavage | Mouse | NTP_ICE_cancer |
Showing 36 of 36 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Chloroacetic acid | 201-178-4 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Chloroacetic acid | - | - |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Chloroacetic acid (CAS 79-11-8) is classified under EU CLP Annex VI as Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B; Aquatic Acute 1 with signal word Danger. Hazard statements: H331; H311; H301; H314; H400. Source: EU CLP Annex VI (ECHA).
Chloroacetic acid has 36 NOAEL studies in the database. The lowest reported value is 2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Chloroacetic acid appears on 3 regulatory/inventory lists including active_ingredient; Europe; Pesticides, inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Occupational exposure limits for Chloroacetic acid are set by ACGIH. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Chloroacetic acid is also indexed as a cosmetic ingredient under the name Chloroacetic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Chloroacetic acid is prohibited in EU cosmetics but has active industrial GHS classifications (H331, H311, H301, H314, H400).
Chloroacetic acid also appears in cosmetics, pharmaceutical, food safety databases.