Danger GHS08GHS06 NOAEL Data REACH Registered Cosmetic Ingredient

Chloroacetamide

Also known as: Acetamide, 2-chloro-, 2-Chloracetamide, BRN 0878191, 2-Chloroethanamide, EINECS 201-174-2 (+1 more)

CAS 79-07-2

Chloroacetamide (CAS 79-07-2) is a chemical substance with GHS signal word Danger; key hazard signal: H361f ***; H301; H317. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Chloroacetamide →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
4
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
Chloroacetamide
CAS Number
79-07-2
DTXSID
DTXSID9041570
Molecular Formula
C2H4ClNO
InChI Key
VXIVSQZSERGHQP-UHFFFAOYSA-N
Monoisotopic Mass
92.998141
Synonyms
Acetamide, 2-chloro-2-ChloracetamideBRN 08781912-ChloroethanamideEINECS 201-174-2UNII-2R97846T1L

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Repr. 2; Acute Tox. 3 *; Skin Sens. 1H361f ***; H301; H317GHS08; GHS06Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsToxic if swallowed Causes mild skin irritation Causes eye irritation May cause allergic skin reaction Suspected of damaging fertility or the unborn child Harmful to aquatic life
Short-term EffectsThe substance is irritating to the eyes and skin.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of ExposureThe substance can be absorbed into the body in hazardous amounts by ingestion. The substance can be absorbed into the body through the skin.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Preservative

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
banned; Europe; Personal careEuropean CommissionCosIng
Europe; Personal careEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
10mg/kg bw/d-intravenousrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
10mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
10mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
10mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=10mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=10mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
20--oralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
40%-oralrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/ d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.07979%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.3661%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.01064%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
0.03571%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
=0.705mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
2R97846T1LUNIIFDA UNII substance identifier--openFDA substances
2R97846T1LUNIIFDA UNII substance identifier--openFDA substances
2R97846T1LUNIIFDA UNII substance identifier--openFDA substances
2R97846T1LUNIIFDA UNII substance identifier--openFDA substances
17.07%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
31.33%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
625ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
968.8ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
99.73ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
283.7ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
13.3ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP_ICE_skin_sensitization
27.68ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP_ICE_skin_sensitization
=70mg/kg bwLD50oralRatNTP_ICE_acute_oral
=138mg/kg bwLD50oralRatNTP_ICE_acute_oral
=275mg/kg bwLD50oralRatNTP_ICE_acute_oral
=290mg/kg bwLD50oralRatNTP_ICE_acute_oral
=306mg/kg bwLD50oralRatNTP_ICE_acute_oral
=221mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=222mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=225mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=341mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=382mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=417mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=3mg/kg bw/dNOAEL--SCCS_vision_codex
=3mg/kg bw/dNOAEL--SCCS_vision_codex
=3mg/kg bw/dNOAEL--SCCS_vision_codex
=3mg/kg bw/dNOAEL--SCCS_vision_codex
=9.6mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=10mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=10mg/kg bw/dNOAELintravenousrabbitSCCS_vision_codex
=10mg/kg bw/dayNOAELoralratSCCS_vision_codex
=10mg/kg bw/dNOAELintravenousrabbitSCCS_vision_codex
=10mg/kg bw/dayNOAELoralratSCCS_vision_codex
=10mg/kg bw/dNOAELintravenousrabbitSCCS_vision_codex
=10mg/kg bw/dayNOAELoralratSCCS_vision_codex
=10mg/kg bw/dNOAELintravenousrabbitSCCS_vision_codex

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-chloroacetamide201-174-2ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1432/1122 March 2011Not safe — not safe under current use conditionsNot safe at 0.3% (current permitted level)Genotoxicity potential; skin sensitization; insufficient margin of safety at authorised level

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL346368
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Chloroacetamide?

Chloroacetamide (CAS 79-07-2) is classified under EU CLP Annex VI as Repr. 2; Acute Tox. 3 *; Skin Sens. 1 with signal word Danger. Hazard statements: H361f ***; H301; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Chloroacetamide?

Chloroacetamide has 100 NOAEL studies in the database. The lowest reported value is 0.01064 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Chloroacetamide?

Chloroacetamide appears on 4 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Indirect additives food contact (10/2018), banned; Europe; Personal care, and 1 more. Source: EPA CPDat.

Is Chloroacetamide used in cosmetics?

Yes, Chloroacetamide is also indexed as a cosmetic ingredient under the name Chloroacetamide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Chloroacetamide come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Chloroacetamide have different safety status in cosmetics vs industrial chemicals?

Chloroacetamide is prohibited in EU cosmetics but has active industrial GHS classifications (H361f, H301, H317).

Is Chloroacetamide used outside industrial chemicals?

Chloroacetamide also appears in cosmetics, pharmaceutical databases.