Also known as: 2-Propenamide, Acrylagel, Amresco Acryl-40, BRN 0605349, EINECS 201-173-7 (+8 more)
CAS 79-06-1
Acrylamide (CAS 79-06-1) is a chemical substance with GHS signal word Danger; key hazard signal: H350; H340; H361f ***; H332; H312; H301; H372 **; H315; H319; H317. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
Acrylamide is classified GHS Danger (H350, H340, H361f, H332, H312, H301, H372, H315) in the chemicals database but is restricted in EU cosmetics at max II/681.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2A | Probably carcinogenic | 1994 | 60, Sup 7 |
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| Acrylamide | Carcinogenic (Article 57a); Mutagenic (Article 57b) | 30-Mar-2010 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
| - | developmental, male | No | Yes | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B; Muta. 1B; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; STOT RE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 | H350; H340; H361f ***; H332; H312; H301; H372 **; H315; H319; H317 | GHS08; GHS06 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Toxic if swallowed Harmful in contact with skin or if inhaled Causes skin irritation Causes serious eye irritation May cause an allergic skin reaction May cause genetic defects May cause cancer Suspected of damaging fertility or the unborn child Causes damage to nervous system Causes damage to the nervous system through prolonged or repeated exposure |
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. The effects may be delayed. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system. This may result in peripheral nerve damage. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. May cause toxicity to human reproduction or development. Repeated or prolonged contact with skin may cause dermatitis. See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 0.3 mg/m³ | - | 0.3 | Y |
| NIOSH | TWA | 0.03 mg/m³ | - | 0.03 | Y |
| CAL/OSHA | TWA | 0.03 mg/m³ | - | 0.03 | Y |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| fracking; water | NY Department of Conservation | CPCat |
| banned; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; drinking_water; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| children; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Food contact items; Toys and children's products | Danish EPA | Danish EPA |
| Europe; Food contact items; Toys and children's products | Danish EPA | Danish EPA |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| banned; Europe; Personal care | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.042 | mg/kg bw/day | BMDL (05 HED) | oral | Rat | ToxValDB_ATSDR_MRLs |
| =0.0170658 | mg/L | BMDL (05) | oral | Rat | ToxValDB_ATSDR_MRLs |
| =0.27 | mg/kg bw/day | BMDL (05) | oral | Rat | ToxValDB_IRIS |
| =0.31 | mg/kg bw/day | BMDL (10 HED) | oral | Rat | ToxValDB_ATSDR_MRLs |
| =0.126285 | mg/L | BMDL (10) | oral | Rat | ToxValDB_ATSDR_MRLs |
| =0.17 | mg/kg bw/day | BMDL (10) | oral | Mouse | ToxValDB_EFSA |
| =0.18 | mg/kg bw/day | BMDL (10) | oral | Mouse | ToxValDB_WHO_JECFA_Tox_Studies |
| =0.31 | mg/kg bw/day | BMDL (10) | oral | Rat | ToxValDB_WHO_JECFA_Tox_Studies |
| =0.43 | mg/kg bw/day | BMDL (10) | oral | Rat | ToxValDB_EFSA |
| =0.18 | mg/m3 | BMDL (HEC) | inhalation | Rat | ToxValDB_IRIS |
| =0.053 | mg/kg bw/day | BMDL (HED) | oral | Rat | ToxValDB_IRIS |
| AB140 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| AB140 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| AB140 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| AB0.2 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB0.2 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB0.2 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 20R035KLCI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20R035KLCI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20R035KLCI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 20R035KLCI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.18 | mg/m^3 | HEC 5 (BMDL) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =0.053 | mg/kg/day | HED (BMDL) | oral | - | EPA_IRIS_iris_rfd_systems.csv |
| 2A | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 0.0001 | ug/m3 | Inhalation risk unit | Inhalation | - | NTP_ICE_cancer |
| >0.0166 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =53 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =124 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >150 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =170 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =175 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| <180 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =202 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =203 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =490 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =565 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =0.0015 | mg/kg bw/day | LOAEL | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v63je01 |
| =0.0015 | mg/kg bw/day | LOAEL | - | Rat; Mouse | INCHEM_WHO_jecfa_jecmono_v63je01 |
| =0.25 | mg/kg bw/day | LOAEL | - | Mouse | INCHEM_WHO_jecfa_jecmono_v63je01 |
| =0.25 | mg/kg bw/day | LOAEL | - | Mouse | INCHEM_WHO_jecfa_jecmono_v63je01 |
| =0.3 | mg/kg bw/day | LOAEL | - | Mouse | INCHEM_WHO_jecfa_jecmono_v63je01 |
| =0.3 | mg/kg bw/day | LOAEL | - | Mouse | INCHEM_WHO_jecfa_jecmono_v63je01 |
| =2.8 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Acrylamide | 201-173-7 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Acrylamide | - | - |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: 10 mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Acrylamide (CAS 79-06-1) is classified under EU CLP Annex VI as Carc. 1B; Muta. 1B; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; STOT RE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 with signal word Danger. Hazard statements: H350; H340; H361f ***; H332; H312; H301; H372 **; H315; H319; H317. Source: EU CLP Annex VI (ECHA).
Acrylamide has 100 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
Acrylamide appears on 11 regulatory/inventory lists including Indirect additives food contact (10/2018), OEHHA Proposition 65 (3/2019), fracking; water, and 8 more. Source: EPA CPDat.
Acrylamide is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 1994). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Acrylamide is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Yes, Acrylamide is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Carcinogenic (Article 57a); Mutagenic (Article 57b). Source: ECHA SVHC Candidate List.
Occupational exposure limits for Acrylamide are set by OSHA, NIOSH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Acrylamide is also indexed as a cosmetic ingredient under the name ACRYLAMIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Acrylamide is classified GHS Danger (H350, H340, H361f, H332, H312, H301, H372, H315) in the chemicals database but is restricted in EU cosmetics at max II/681.
Acrylamide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.