What is the NOAEL for 2-Methylpropanal?
2-Methylpropanal has 46 NOAEL studies in the database. The lowest reported value is 0.17 %/sec via Ocular. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Methylpropanal
Also known as: Isobutyraldehyde, EINECS 201-149-6, FEMA No. 2220, Isopropyl aldehyde, alpha-Methylpropionaldehyde (+14 more)
CAS 78-84-2
2-Methylpropanal (CAS 78-84-2) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, EPA TRI.
Cross-Vertical Regulatory Divergence
2-Methylpropanal is classified GHS Danger (H225, H319, H302, H320, H335, H373, H402, H341) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
46
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
2-Methylpropanal
CAS Number
78-84-2
DTXSID
DTXSID9021635
Molecular Formula
C4H8O
InChI Key
AMIMRNSIRUDHCM-UHFFFAOYSA-N
Monoisotopic Mass
72.057515
Synonyms
IsobutyraldehydeEINECS 201-149-6FEMA No. 2220Isopropyl aldehydealpha-MethylpropionaldehydeNCI-C60968Propionaldehyde, 2-methyl-UNII-C42E28168L2-METHYL-PROPANAL2-Methyl-Propionaldehyde2-Methylpropanal (isobutanal)2-Methylpropanal oxime
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Harmful if swallowed Causes eye irritation May cause respiratory irritation May be harmful if swallowed and enters airways Harmful to aquatic life |
| Short-term Effects | The substance is irritating to the eyes. The substance at very high concentrations is irritating to the upper respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. Medical observation is indicated. The substance may cause effects on nervous system. Exposure could cause lowering of consciousness. |
| Long-term Effects | Repeated or chronic inhalation of the vapour may cause chronic inflammation of the upper respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
FragranceSoftener and conditionerNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 46 of 46 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =120 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| C42E28168L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C42E28168L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C42E28168L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C42E28168L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 0.17 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.17 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.17 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.17 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >23.6 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =47186.8 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| 30 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 30 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 30 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| 30 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| =3000 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >=12000 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =125 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >219 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >219 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >300 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =340 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =340 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >1450 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >1450 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| >2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| >2500 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 27.5 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 27.5 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 27.5 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 27.5 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 2000 | ppm | Top dose | Inhalation | Rat | NTP_ICE_cancer |
Showing 46 of 46 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isobutyraldehyde | 201-149-6 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
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EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Isobutyraldehyde | - | - |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ISOBUTYRALDEHYDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methylpropanal?
2-Methylpropanal appears on 7 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, Europe, air; detected; emissions; Europe; Toys and children's products, and 4 more. Source: EPA CPDat.
Is 2-Methylpropanal used in cosmetics?
Yes, 2-Methylpropanal is also indexed as a cosmetic ingredient under the name 2-Methylpropanal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methylpropanal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Methylpropanal have different safety status in cosmetics vs industrial chemicals?
2-Methylpropanal is classified GHS Danger (H225, H319, H302, H320, H335, H373, H402, H341) in the chemicals database but is allowed in EU cosmetics.
Is 2-Methylpropanal used outside industrial chemicals?
2-Methylpropanal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.