Danger GHS02GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

2-Methyl-1-propanol

Also known as: Isobutyl alcohol, 4-01-00-01588, BRN 1730878, EINECS 201-148-0, FEMA No. 2179 (+15 more)

CAS 78-83-1

2-Methyl-1-propanol (CAS 78-83-1) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H335; H336; H315; H318. Key regulatory status: REACH registered, 20 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for 2-Methylpropanol (Isobutanol) →

Cross-Vertical Regulatory Divergence

2-Methyl-1-propanol is classified GHS Danger (H226, H335, H336, H315, H318) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

2-Methyl-1-propanol

CAS Number

78-83-1

DTXSID

DTXSID0021759

Molecular Formula

C4H10O

InChI Key

ZXEKIIBDNHEJCQ-UHFFFAOYSA-N

Monoisotopic Mass

74.073165

Synonyms

Isobutyl alcohol4-01-00-01588BRN 1730878EINECS 201-148-0FEMA No. 2179FEMA Number 2179Fermentation butyl alcoholRCRA waste number U140UNII-56F9Z98TEM1-hydroxymethylpropane2-Methyl-1-propanyl alcohol2-MethylpropanoI

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; STOT SE 3; STOT SE 3; Skin Irrit. 2; Eye Dam. 1	H226; H335; H336; H315; H318	GHS02; GHS07; GHS05	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is severely irritating to the eyes. The substance is irritating to the skin. Exposure far above the OEL could cause lowering of consciousness. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	100 ppm (300 mg/m³)	100	300	N
NIOSH	TWA	50 ppm (150 mg/m³)	50	150	N
ACGIH	TWA	50 ppm [1973]	50	-	N
CAL/OSHA	TWA	50 ppm (150 mg/m³)	50	150	N
NIOSH	IDLH	1600 ppm	1600	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 26 records

FragranceNo specific technical functionSolventFlavouring and nutrientAdhesion/cohesion promoterPlasticizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 20 records

List	Keyword	Source
air; detected; emissions; Europe; Furniture and Furnishings	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; Construction and building materials; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - shoes; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - shoes; Europe	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Europe	European Commission	Fl@vis
air; detected; emissions; Europe; Home maintenance - caulk/sealant	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 60 studies

Value	Unit	Endpoint	Route	Species	Source
<=0.3	mg/kg bw/day	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=0.3	mg/kg bw/day	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=310	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
60.3	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
1	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
56F9Z98TEM	UNII	FDA UNII substance identifier	-	-	openFDA substances
56F9Z98TEM	UNII	FDA UNII substance identifier	-	-	openFDA substances
56F9Z98TEM	UNII	FDA UNII substance identifier	-	-	openFDA substances
2	unitless	GHS Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
0.24	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
>6.5	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>18.18	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
19.2	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>21.1	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
24.6	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=2460	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>2830	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3100	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3350	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=51537.7	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=1000	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_IRIS
10	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
=0.1	mg/m3	NOAEL	-	-	INCHEM_WHO_hsg_hsg_hsg009
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=50	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=50	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=125	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=125	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=125	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
160	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
>219	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>219	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>219	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>300	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>300	mg/kg bw/day	NOAEL	oral: feed	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=316	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HESS
=340	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=340	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=340	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
>1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>1000	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1000	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
1251	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
>1450	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
>1450	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
>1450	mg/kg bw/day	NOAEL	oral: drinking water	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=2432	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HESS
>2500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA

Showing 50 of 60 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-methylpropan-1-ol	201-148-0	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ISOBUTANOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Methyl-1-propanol?

2-Methyl-1-propanol (CAS 78-83-1) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3; STOT SE 3; Skin Irrit. 2; Eye Dam. 1 with signal word Danger. Hazard statements: H226; H335; H336; H315; H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Methyl-1-propanol?

2-Methyl-1-propanol has 60 NOAEL studies in the database. The lowest reported value is 0.24 %/sec via Ocular. Source: NTP_ICE_eye_irritation.

What regulatory lists include 2-Methyl-1-propanol?

2-Methyl-1-propanol appears on 16 regulatory/inventory lists including air; detected; emissions; Europe; Furniture and Furnishings, air; detected; emissions; Europe; Other indirect contact consumer goods, air; Construction and building materials; detected; emissions; Europe, and 13 more. Source: EPA CPDat.

What are the occupational exposure limits for 2-Methyl-1-propanol?

Occupational exposure limits for 2-Methyl-1-propanol are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-Methyl-1-propanol used in cosmetics?

Yes, 2-Methyl-1-propanol is also indexed as a cosmetic ingredient under the name 2-Methylpropanol (Isobutanol). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-1-propanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methyl-1-propanol have different safety status in cosmetics vs industrial chemicals?

2-Methyl-1-propanol is classified GHS Danger (H226, H335, H336, H315, H318) in the chemicals database but is allowed in EU cosmetics.

Is 2-Methyl-1-propanol used outside industrial chemicals?

2-Methyl-1-propanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.