What is the NOAEL for Linalool?
Linalool has 64 NOAEL studies in the database. The lowest reported value is 0 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Linalool
Also known as: 3,7-Dimethyl-1,6-octadien-3-ol, 3,7-Dimethyl-3-hydroxy-1,6-octadiene, 3,7-Dimethyl-3-ol-1,6-octadiene, Phantol, 1,6-octadien-3-ol, 3,7-dimetil - (+14 more)
CAS 78-70-6
Linalool (CAS 78-70-6) is a chemical substance. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
64
SOURCE
Chemical inventory jurisdictions
Regulatory lists
60
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Linalool
CAS Number
78-70-6
DTXSID
DTXSID7025502
Molecular Formula
C10H18O
InChI Key
CDOSHBSSFJOMGT-UHFFFAOYSA-N
Monoisotopic Mass
154.135765
Synonyms
3,7-Dimethyl-1,6-octadien-3-ol3,7-Dimethyl-3-hydroxy-1,6-octadiene3,7-Dimethyl-3-ol-1,6-octadienePhantol1,6-octadien-3-ol, 3,7-dimetil -EC No.: 201-134-40-01-00-00462BRN 1721488Caswell No. 526A3,7-Dimethylocta-1,6-dien-3-olEINECS 201-134-4EPA Pesticide Chemical Code 128838
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Long-term Effects | The substance may have effects on the liver. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| air; consumer_product; detected; emissions | Elsevier | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 64 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-0.050.05 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-0.050.05 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| 68.3 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 41.39 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 94.804 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 290 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| =24.58 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| - | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 1.3 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 1.4 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 7.9 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 1.35 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 3.95 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 30 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 30 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 30 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 30 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 55 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| D81QY6I88E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D81QY6I88E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D81QY6I88E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| D81QY6I88E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.22 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 4966 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 12960 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 15000 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| >2440 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =2790 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| <3180 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =300 | mg/kg bw/day | LEL | oral | Chicken | EFSA |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| =117 | mg/kg bw/day | NOAEL | oral | Rat | EFSA |
| =117 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA |
| =117 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA |
| =117 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA |
| =117 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA |
| =160 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HESS |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =0.019 | mg/kg bw/day | NOEL | - | - | WHO/JECFA |
| =0.019 | mg/kg bw/day | NOEL | - | - | WHO/JECFA |
| =0.05 | mg/kg bw/day | NOEL | - | - | WHO/JECFA |
| =0.05 | mg/kg bw/day | NOEL | - | - | WHO/JECFA |
| >50 | mg/kg bw/day | NOEL | - | Rat | WHO/JECFA |
Showing 50 of 64 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Linalool | 201-134-4 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Mandatory individual label declaration above 10 ppm in leave-on products, 100 ppm in rinse-off products (EU 26 allergen list). IFRA 51st Amendment imposes stricter limits on linalool hydroperoxide content in formulations.
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
LINALOOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Linalool?
Linalool appears on 28 regulatory/inventory lists including Europe; Personal care; restricted, Europe, Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe, and 25 more. Source: EPA CPDat.
Is Linalool used in cosmetics?
Yes, Linalool is also indexed as a cosmetic ingredient under the name Linalool. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Linalool come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Linalool used outside industrial chemicals?
Linalool also appears in cosmetics, pharmaceutical, cannabis databases.