What is the NOAEL for Calcium pyrophosphate?
Calcium pyrophosphate has 8 NOAEL studies in the database. The lowest reported value is X69NU20D19 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Calcium pyrophosphate
Also known as: Diphosphoric acid, calcium salt (1:2), C 54-80, Calcium diphosphate (Ca2P2O7), Calcium metaphosphate oxide (Ca0.67(PO3)0.66O0.34), Calcium phosphate (Ca2P2O7) (+8 more)
CAS 7790-76-3
Calcium pyrophosphate (CAS 7790-76-3) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Calcium pyrophosphate
CAS Number
7790-76-3
DTXSID
DTXSID50872512
Molecular Formula
2Ca.H4O7P2
InChI Key
JUNWLZAGQLJVLR-UHFFFAOYSA-J
Monoisotopic Mass
257.868408
Synonyms
Diphosphoric acid, calcium salt (1:2)C 54-80Calcium diphosphate (Ca2P2O7)Calcium metaphosphate oxide (Ca0.67(PO3)0.66O0.34)Calcium phosphate (Ca2P2O7)Calcium pyrophosphate (Ca2P2O7)CALCIUMPYROPHOSPHAT(2:1)Dicalcium diphosphatedicalcium pyrophosphateDicalciumpyrophosphatNP 970-10Pyrophosphate de dicalcium
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
AbrasiveStabilizing agentFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| X69NU20D19 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X69NU20D19 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X69NU20D19 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X69NU20D19 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 30 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| >30 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =240 | mg/kg bw/day | NOAEL (HED) | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =8 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dicalcium pyrophosphate | 232-221-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E450vi — ADI: 40 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Calcium pyrophosphate?
Calcium pyrophosphate appears on 2 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Calcium pyrophosphate used in cosmetics?
Yes, Calcium pyrophosphate is also indexed as a cosmetic ingredient under the name Calcium Pyrophosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium pyrophosphate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Calcium pyrophosphate used outside industrial chemicals?
Calcium pyrophosphate also appears in cosmetics, food safety, cannabis databases.