NOAEL Data REACH Registered Cosmetic Ingredient

7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole

Also known as: Oxazolidine E (1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-) (Oxazolidine-E), Oxazolidine-E, 1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-, 1-Aza-5-ethyl-3,7-dioxabicyclo(3.3.0)octane, EINECS 231-810-4 (+8 more)

CAS 7747-35-5

7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole (CAS 7747-35-5) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 7-Ethylbicyclooxazolidine →

SOURCE noael studies public
NOAEL studies
48
SOURCE chemical inventory jurisdictions
Regulatory lists
10
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields
Name
7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole
CAS Number
7747-35-5
DTXSID
DTXSID3029289
Molecular Formula
C7H13NO2
InChI Key
ZRCMGIXRGFOXNT-UHFFFAOYSA-N
Monoisotopic Mass
143.094629
Synonyms
Oxazolidine E (1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-) (Oxazolidine-E)Oxazolidine-E1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-1-Aza-5-ethyl-3,7-dioxabicyclo(3.3.0)octaneEINECS 231-810-45-Ethyl-1-aza-3,7-dioxabicyclo[3.3.0]octaneBioban CS 1246Chemtan A 60Neosyn TXParamel TX 50Zoldine ZEOxazolidine E

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
PreservativeBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records
ListKeywordSource
Europe; Personal careEuropean CommissionCosIng
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 48 of 48 studies
ValueUnitEndpointRouteSpeciesSource
=14.79mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
20E75SVO7AUNIIFDA UNII substance identifier--openFDA substances
20E75SVO7AUNIIFDA UNII substance identifier--openFDA substances
20E75SVO7AUNIIFDA UNII substance identifier--openFDA substances
20E75SVO7AUNIIFDA UNII substance identifier--openFDA substances
=3674mg/kg bwLD50oralRat (Male/Female)NTP_ICE_acute_oral
=5249mg/kg bwLD50oralRat (Male/Female)NTP_ICE_acute_oral
>15mg/kg bw/dayLELoraldog (beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=25mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=25mg/kg bw/dayLELoralratToxRefDB_ToxRefDB_v3_pod.csv
=50mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=50mg/kg bw/dayLELoralratToxRefDB_ToxRefDB_v3_pod.csv
=150mg/kg bw/dayLELoralRabbitToxValDB_ToxRefDB
=150mg/kg bw/dayLELoralrabbit (new zealand white; New Zealand White)ToxRefDB_ToxRefDB_v3_pod.csv
=500mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=500mg/kg bw/dayLELoralrat (Crl:CD BR)ToxRefDB_ToxRefDB_v3_pod.csv
=650mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=650mg/kg bw/dayLELoralrat (Spraque-Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=750mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=750mg/kg bw/dayLELoralrat (Crl:CD BR)ToxRefDB_ToxRefDB_v3_pod.csv
=1500mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=1500mg/kg bw/dayLELoralrat (Crl:CD BR)ToxRefDB_ToxRefDB_v3_pod.csv
500mg/kg bw/dayLOELOralRatNTP_ICE_dart
650mg/kg bw/dayLOELOralRatNTP_ICE_dart
650mg/kg bw/dayLOELOralRatNTP_ICE_dart
650mg/kg bw/dayLOELOralRatNTP_ICE_dart
650mg/kg bw/dayLOELOralRatNTP_ICE_dart
650mg/kg bw/dayLOELOralRatNTP_ICE_dart
650mg/kg bw/dayLOELOralRatNTP_ICE_dart
650mg/kg bw/dayLOELOralRatNTP_ICE_dart
750mg/kg bw/dayLOELOralRatNTP_ICE_dart
750mg/kg bw/dayLOELOralRatNTP_ICE_dart
750mg/kg bw/dayLOELOralRatNTP_ICE_dart
-unitlessModel Score--NTP_ICE_endocrine
=5mg/kg bw/dayNELoralratToxRefDB_ToxRefDB_v3_pod.csv
=10mg/kg bw/dayNELoralratToxRefDB_ToxRefDB_v3_pod.csv
=50mg/kg bw/dayNELoralRabbitToxValDB_ToxRefDB
=50mg/kg bw/dayNELoralrabbit (new zealand white; New Zealand White)ToxRefDB_ToxRefDB_v3_pod.csv
=250mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=250mg/kg bw/dayNELoralrat (Crl:CD BR)ToxRefDB_ToxRefDB_v3_pod.csv
=500mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=1000mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=1000mg/kg bw/dayNELoralrat (Crl:CD BR)ToxRefDB_ToxRefDB_v3_pod.csv
=15mg/kg bw/dayNOAELoralDogToxValDB_ECHA_IUCLID
=5mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID
=10mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID
=100mg/kg bw/dayNOELdermalRatToxValDB_ECHA_IUCLID
=150mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID

Showing 48 of 48 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered7a-ethyldihydro-1H,3H,5H-oxazolo[3,4-c]oxazole231-810-4ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
Preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3183106
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole?

7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole has 48 NOAEL studies in the database. The lowest reported value is 14.79 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole?

7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole appears on 4 regulatory/inventory lists including Europe; Personal care, inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, and 1 more. Source: EPA CPDat.

Is 7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole used in cosmetics?

Yes, 7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole is also indexed as a cosmetic ingredient under the name 7-Ethylbicyclooxazolidine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole have different safety status in cosmetics vs industrial chemicals?

7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole is classified GHS Danger (H315, H317, H318, H319, H332, H335, H412) in the chemicals database but is restricted in EU cosmetics at max 0.1%.

Is 7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole used outside industrial chemicals?

7a-Ethyldihydro-1H,3H,5H-oxazolo(3,4-c)oxazole also appears in cosmetics, pharmaceutical databases.