Danger GHS03GHS07GHS08 NOAEL Data REACH Registered Cosmetic Ingredient

Diammonium peroxydisulfate

Also known as: Peroxydisulfuric acid, diammonium salt, EINECS 231-786-5, Persulfate d'ammonium, UNII-22QF6L357F

CAS 7727-54-0

Diammonium peroxydisulfate (CAS 7727-54-0) is a chemical substance with GHS signal word Danger; key hazard signal: H272; H302; H335; H315; H319; H334; H317. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Ammonium Persulfate →

SOURCE noael studies public
NOAEL studies
53
SOURCE chemical inventory jurisdictions
Regulatory lists
4
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields
Name
Diammonium peroxydisulfate
CAS Number
7727-54-0
DTXSID
DTXSID9029691
Molecular Formula
2H3N.H2O8S2
InChI Key
ROOXNKNUYICQNP-UHFFFAOYSA-N
Monoisotopic Mass
227.972208
Synonyms
Peroxydisulfuric acid, diammonium saltEINECS 231-786-5Persulfate d'ammoniumUNII-22QF6L357F

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Ox. Sol. 3; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; Skin Sens. 1H272; H302; H335; H315; H319; H334; H317GHS03; GHS07; GHS08Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract. Inhalation of dust may cause asthma-like reactions.
Long-term EffectsRepeated or prolonged inhalation may cause asthma. Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. May cause a general allergic reaction, such as urticaria or shock.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 10 records
Oxidizing agentBleaching agentCatalystChemical reaction regulatorBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
frackingFracFocusFracFocus
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
fracking; waterNY Department of ConservationCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 53 studies
ValueUnitEndpointRouteSpeciesSource
=0.824mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
2%EC3DermalMouseNTP_ICE_skin_sensitization
2%EC3DermalMouseNTP_ICE_skin_sensitization
2%EC3DermalMouseNTP_ICE_skin_sensitization
2%EC3DermalMouseNTP_ICE_skin_sensitization
22QF6L357FUNIIFDA UNII substance identifier--openFDA substances
22QF6L357FUNIIFDA UNII substance identifier--openFDA substances
22QF6L357FUNIIFDA UNII substance identifier--openFDA substances
22QF6L357FUNIIFDA UNII substance identifier--openFDA substances
>=2.95mg/LLC50Inhalation-NTP_ICE_acute_inhalation
>5.1mg/LLC50Inhalation-NTP_ICE_acute_inhalation
>42.9mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=5mg/m3NOAELoralratCIR_vision_codex
=5mg/m3NOAELoralratCIR_vision_codex
=5mg/m3NOAELoralratCIR_vision_codex
=5mg/m3NOAELoralratCIR_vision_codex
=10.3mg/m3NOAELoralratCIR_vision_codex
=10.3mg/m3NOAELoralratCIR_vision_codex
=10.3mg/m3NOAELoralratCIR_vision_codex
=10.3mg/m3NOAELoralratCIR_vision_codex
=25mg/m3NOAELinhalationratCIR_vision_codex
=25mg/m3NOAELinhalationratCIR_vision_codex
=25mg/m3NOAELinhalationratCIR_vision_codex
=25mg/m3NOAELinhalationratCIR_vision_codex
=41.1mg/kg bw/dNOAELoralratCIR_vision_codex
=41.1mg/kg bw/dNOAELoralratCIR_vision_codex
=41.1mg/kg bw/dNOAELoralratCIR_vision_codex
=41.1mg/kg bw/dNOAELoralratCIR_vision_codex
>80mg/kg bwNOAELoralratCIR_vision_codex
>80mg/kg bwNOAELoralratCIR_vision_codex
>80mg/kg bwNOAELoralratCIR_vision_codex
>80mg/kg bwNOAELoralratCIR_vision_codex
=131.5mg/kg bw/dNOAELoralratCIR_vision_codex
=131.5mg/kg bw/dNOAELoralratCIR_vision_codex
=131.5mg/kg bw/dNOAELoralratCIR_vision_codex
=131.5mg/kg bw/dNOAELoralratCIR_vision_codex
=200mg/kg bw/dNOAELoralratCIR_vision_codex
=200mg/kg bw/dNOAELoralratCIR_vision_codex
=200mg/kg bw/dNOAELoralratCIR_vision_codex
=200mg/kg bw/dNOAELoralratCIR_vision_codex
=250mg/kg/dNOAEL--CIR_vision_codex
=250mg/kg/dNOAEL--CIR_vision_codex
=250mg/kg/dNOAEL--CIR_vision_codex
=250mg/kg/dNOAEL--CIR_vision_codex
5mg/m3developmental toxicityoralratUnifiedCodex:CIR:beta.noael_studies
5mg/m3developmental toxicityoralratUnifiedCodex:CIR:beta.noael_studies
10.3mg/m3developmental toxicityoralratUnifiedCodex:CIR:beta.noael_studies
25mg/m3inhalation toxicityinhalationratUnifiedCodex:CIR:beta.noael_studies
41.1mg/kg bw/dinhalation toxicityoralratUnifiedCodex:CIR:beta.noael_studies
131.5mg/kg bw/dinhalation toxicityoralratUnifiedCodex:CIR:beta.noael_studies

Showing 50 of 53 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredDiammonium peroxodisulphate231-786-5ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the person introducing this chemical must tell us in writing within 28 calendar days that the circumstances have occurred. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Minerals
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL2447905
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Diammonium peroxydisulfate?

Diammonium peroxydisulfate (CAS 7727-54-0) is classified under EU CLP Annex VI as Ox. Sol. 3; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; Skin Sens. 1 with signal word Danger. Hazard statements: H272; H302; H335; H315; H319; H334; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Diammonium peroxydisulfate?

Diammonium peroxydisulfate has 53 NOAEL studies in the database. The lowest reported value is 0.824 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Diammonium peroxydisulfate?

Diammonium peroxydisulfate appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, fracking, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.

Is Diammonium peroxydisulfate used in cosmetics?

Yes, Diammonium peroxydisulfate is also indexed as a cosmetic ingredient under the name Ammonium Persulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Diammonium peroxydisulfate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Diammonium peroxydisulfate have different safety status in cosmetics vs industrial chemicals?

Diammonium peroxydisulfate is classified GHS Danger (H272, H302, H335, H315, H319, H334, H317) in the chemicals database but is allowed in EU cosmetics.

Is Diammonium peroxydisulfate used outside industrial chemicals?

Diammonium peroxydisulfate also appears in cosmetics, pharmaceutical databases.