NOAEL Data REACH Registered Cosmetic Ingredient

Ferric chloride

Also known as: Iron(III) chloride (Ferric chloride) (Iron chloride), Caswell No. 459, EINECS 231-729-4, EPA Pesticide Chemical Code 034901, Iron chloride (+7 more)

CAS 7705-08-0

Ferric chloride (CAS 7705-08-0) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Ferric Chloride →

Cross-Vertical Regulatory Divergence

Ferric chloride is classified GHS Danger (H302, H314, H315, H318, H412, H335, H371, H304) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

Ferric chloride

CAS Number

7705-08-0

DTXSID

DTXSID8020622

Molecular Formula

3ClH.Fe

InChI Key

RBTARNINKXHZNM-UHFFFAOYSA-K

Monoisotopic Mass

163.864969

Synonyms

Iron(III) chloride (Ferric chloride) (Iron chloride)Caswell No. 459EINECS 231-729-4EPA Pesticide Chemical Code 034901Iron chlorideIron sesquichlorideNatural molysiteChlorure ferriqueChlorure perriquePerchlorure de ferFeCl3[FeCl3]

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. Corrosive on ingestion.
Routes of Exposure	The substance can be absorbed into the body by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records

AstringentProcessing aids not otherwise specifiedChemical reaction regulatorFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records

List	Keyword	Source
active_ingredient; Australia	Australian Pesticides and Veterinary Medicines Authority	CPCat
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
fracking; water	NY Department of Conservation	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
pharmaceutical	US International Trade Commission	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 20 of 20 studies

Value	Unit	Endpoint	Route	Species	Source
14.98	min	Breakthrough Time	Dermal	-	NTP_ICE_skin_irritation
27.29	min	Breakthrough Time	Dermal	-	NTP_ICE_skin_irritation
U38V3ZVV3V	UNII	FDA UNII substance identifier	-	-	openFDA substances
U38V3ZVV3V	UNII	FDA UNII substance identifier	-	-	openFDA substances
U38V3ZVV3V	UNII	FDA UNII substance identifier	-	-	openFDA substances
U38V3ZVV3V	UNII	FDA UNII substance identifier	-	-	openFDA substances
=95	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=108	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=277	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=314	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
336	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1000	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
28.3	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
43.1	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
50.6	%	Viability (240 minutes)	Dermal	-	NTP_ICE_skin_irritation
77.6	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
78	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
80.4	%	Viability (3 minutes)	Dermal	-	NTP_ICE_skin_irritation
58.6	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation
89.6	%	Viability (60 minutes)	Dermal	-	NTP_ICE_skin_irritation

Showing 20 of 20 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Iron trichloride	231-729-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Ferric chloride?

Ferric chloride has 20 NOAEL studies in the database. The lowest reported value is 14.98 min via Dermal. Source: NTP_ICE_skin_irritation.

What regulatory lists include Ferric chloride?

Ferric chloride appears on 8 regulatory/inventory lists including active_ingredient; Australia, inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 5 more. Source: EPA CPDat.

Is Ferric chloride used in cosmetics?

Yes, Ferric chloride is also indexed as a cosmetic ingredient under the name Ferric Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ferric chloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Ferric chloride have different safety status in cosmetics vs industrial chemicals?

Ferric chloride is classified GHS Danger (H302, H314, H315, H318, H412, H335, H371, H304) in the chemicals database but is allowed in EU cosmetics.

Is Ferric chloride used outside industrial chemicals?

Ferric chloride also appears in cosmetics, pharmaceutical, cannabis databases.