What is the NOAEL for Acetyltriethyl citrate?
Acetyltriethyl citrate has 8 NOAEL studies in the database. The lowest reported value is 5WBR36T90E UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acetyltriethyl citrate
Also known as: 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester, 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, 1,2,3-triethyl ester, 3-03-00-01105, BRN 1804947, Citric acid, acetyl triethyl ester (+9 more)
CAS 77-89-4
Acetyltriethyl citrate (CAS 77-89-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Acetyltriethyl citrate
CAS Number
77-89-4
DTXSID
DTXSID5044576
Molecular Formula
C14H22O8
InChI Key
WEAPVABOECTMGR-UHFFFAOYSA-N
Monoisotopic Mass
318.131468
Synonyms
1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, 1,2,3-triethyl ester3-03-00-01105BRN 1804947Citric acid, acetyl triethyl esterCitroflex A 2EINECS 201-066-5NSC 3887Tricarballylic acid, beta-acetoxytributyl esterTriethyl 2-acetoxy-1,2,3-propanetricarboxylateTriethyl acetylcitrateTriethyl citrate, acetate
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
20 records
Film formerPlasticizerDeodorizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 5WBR36T90E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5WBR36T90E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5WBR36T90E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5WBR36T90E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =7000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| >=400 | mg/kg bw/day | NOAEL | oral | Mouse | ECHA |
| ~1000 | ppm | NOAEL | oral | Rat | ECHA |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Triethyl O-acetylcitrate | 201-066-5 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ACETYLTRIETHYL CITRATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Acetyltriethyl citrate?
Acetyltriethyl citrate appears on 3 regulatory/inventory lists including Indirect additives food contact (10/2018), IFRA Transparency, consumer_product. Source: EPA CPDat.
Is Acetyltriethyl citrate used in cosmetics?
Yes, Acetyltriethyl citrate is also indexed as a cosmetic ingredient under the name Acetyl Triethyl Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetyltriethyl citrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Acetyltriethyl citrate used outside industrial chemicals?
Acetyltriethyl citrate also appears in cosmetics, pharmaceutical databases.