What is the NOAEL for Acetic acid alpha-tocopherol?
Acetic acid alpha-tocopherol has 15 NOAEL studies in the database. The lowest reported value is 73.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acetic acid alpha-tocopherol
Also known as: 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate, 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ylacetat (+8 more)
CAS 7695-91-2
Acetic acid alpha-tocopherol (CAS 7695-91-2) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
12
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Acetic acid alpha-tocopherol
CAS Number
7695-91-2
DTXSID
DTXSID20859032
Molecular Formula
C31H52O3
InChI Key
ZAKOWWREFLAJOT-UHFFFAOYSA-N
Monoisotopic Mass
472.391646
Synonyms
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ylacetat[2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] acetate2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl acetateacetate de 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyranne-6-yleacetato de 3,4-dihidro-2,5,7,8-tetrametil-2-(4,8,12-trimetiltridecil)-2H-benzopirano-6-iloEINECS 231-710-0Vitamin E acetateEC No.: 231-710-0
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
29 records
PreservativeAntioxidantFragrancePharmaceuticalSoftener and conditionerHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =73.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9E8X80D2L0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9E8X80D2L0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9E8X80D2L0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9E8X80D2L0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WR1WPI7EW8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WR1WPI7EW8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WR1WPI7EW8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| WR1WPI7EW8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=360 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =540 | mg/day | NOAEL | oral | Human | ToxValDB_EFSA |
| =540 | mg/day | NOAEL | - | Human | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1600 | mg/kg bw/day | NOAEL | oral | Hamster | ToxValDB_ECHA_IUCLID |
| >2000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate | 231-710-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Acetic acid alpha-tocopherol?
Acetic acid alpha-tocopherol appears on 8 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, SCIL (9/2019), and 5 more. Source: EPA CPDat.
Is Acetic acid alpha-tocopherol used in cosmetics?
Yes, Acetic acid alpha-tocopherol is also indexed as a cosmetic ingredient under the name Vitamin E Oil. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetic acid alpha-tocopherol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Acetic acid alpha-tocopherol used outside industrial chemicals?
Acetic acid alpha-tocopherol also appears in cosmetics, food safety, cannabis databases.