Danger GHS06 NOAEL Data REACH Registered Cosmetic Ingredient

Sodium fluoride

Also known as: Fluoride, sodium, Sodium fluoride (NaF), Alcoa sodium fluoride, Caswell No. 769, Cavi-trol (+15 more)

CAS 7681-49-4

Sodium fluoride (CAS 7681-49-4) is a chemical substance with GHS signal word Danger; key hazard signal: H301; H315; H319. Key regulatory status: REACH registered, 32 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Sodium Fluoride →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
32
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
Sodium fluoride
CAS Number
7681-49-4
DTXSID
DTXSID2020630
Molecular Formula
FH.Na
InChI Key
PUZPDOWCWNUUKD-UHFFFAOYSA-M
Synonyms
Fluoride, sodiumSodium fluoride (NaF)Alcoa sodium fluorideCaswell No. 769Cavi-trolDisodium difluorideEINECS 231-667-8EPA Pesticide Chemical Code 075202FlozengesFluonatrilFluoridentFluorineed

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 3 *; Skin Irrit. 2; Eye Irrit. 2H301; H315; H319GHS06Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract. Ingestion could cause hypocalcaemia and hypokalaemia. This may result in central nervous system disorders and cardiac disorders.
Long-term EffectsThe substance may have effects on the bones and teeth. This may result in fluorosis.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 37 records
PharmaceuticalBiocideThickening agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 32 records
ListKeywordSource
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
inert_ingredient; PesticidesEPACPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
Europe; supplementsEUCPCat
Europe; food_additive; supplementsEUCPCat
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - dental care - toothpasteDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank
Europe; Personal care - oral and dental care - teeth whitenerDanish Environmental Protection AgencyDanish EPA
PesticidesNational Park ServiceCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
=2.5mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
8ZYQ1474W7UNIIFDA UNII substance identifier--openFDA substances
8ZYQ1474W7UNIIFDA UNII substance identifier--openFDA substances
8ZYQ1474W7UNIIFDA UNII substance identifier--openFDA substances
8ZYQ1474W7UNIIFDA UNII substance identifier--openFDA substances
=1.3mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=1.3mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=2.4mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=2.4mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=2.8mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=2.8mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=5mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=15mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=15mg/kg bw/dayLELoralmouse (B6C3F1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=20mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
~22.3mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=120mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=120mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
>=6.3mg/kg bw/dayLOAECoralMouseToxValDB_ECHA_IUCLID
~4mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=5mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=7.5mg/kg bw/dayLOAELoralMouseToxValDB_ToxRefDB
=7.5mg/kg bw/dayLOAELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
~12.6mg/kg bw/dayLOAELoralMouseToxValDB_ECHA_IUCLID
=15mg/kg bw/dayLOAELoralRatToxValDB_ToxRefDB
=15mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=30mg/kg bw/dayLOAELoralMouseToxValDB_ToxRefDB
=30mg/kg bw/dayLOAELoralmouse (B6C3F1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=52.75mg/kg bw/dayLOAELoralMinkToxValDB_DOE_Wildlife_Benchmarks
~250ppmLOECoralRatToxValDB_ECHA_IUCLID
=0.072mg/mLLOELdermalRatToxValDB_ECOTOX
=0.113mgLOELoralMouseToxValDB_HAWC_Project
=0.1638mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=0.27mg/kg bw/dayLOELoralRatToxValDB_HAWC_Project
=0.36mg/kg bw/dayLOELoralRatToxValDB_HAWC_Project
=0.58mg/kg bw/dayLOELoralMouseToxValDB_HAWC_Project
=0.7mg/kg bw/dayLOELoralDogToxValDB_ECOTOX
=0.9mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=1mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=1.36mg/kg bw/dayLOELoralRatToxValDB_HAWC_Project
=1.63mg/kg bw/dayLOELoralRatToxValDB_HAWC_Project
=1.8mg/kg bw/dayLOELoralRatToxValDB_HAWC_Project
=1.94mg/L serumLOELoralRatToxValDB_HAWC_Project
=2.16mg/L urineLOELoralRatToxValDB_HAWC_Project
=2.21mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=2.99mg/LLOELoralMouseToxValDB_ECOTOX
=3.12mg/kg bw/dayLOELoralRatToxValDB_HAWC_Project
=3.27mg/kg bw/dayLOELoralRatToxValDB_HAWC_Project
=4.2mg/300 gLOELinjectionRatToxValDB_ECOTOX
=4.35mg/kg bw/dayLOELoralRatToxValDB_HAWC_Project

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredSodium fluoride231-667-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Other
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL SODIUM FLUORIDE
ChEMBL Phase
4
Adverse Events
2352
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Sodium fluoride?

Sodium fluoride (CAS 7681-49-4) is classified under EU CLP Annex VI as Acute Tox. 3 *; Skin Irrit. 2; Eye Irrit. 2 with signal word Danger. Hazard statements: H301; H315; H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Sodium fluoride?

Sodium fluoride has 100 NOAEL studies in the database. The lowest reported value is 2.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Sodium fluoride?

Sodium fluoride appears on 14 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, inert_ingredient; Pesticides, and 11 more. Source: EPA CPDat.

Is Sodium fluoride used in cosmetics?

Yes, Sodium fluoride is also indexed as a cosmetic ingredient under the name Sodium Fluoride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sodium fluoride come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Sodium fluoride have different safety status in cosmetics vs industrial chemicals?

Sodium fluoride is classified GHS Danger (H301, H315, H319) in the chemicals database but is restricted in EU cosmetics.

Is Sodium fluoride used outside industrial chemicals?

Sodium fluoride also appears in cosmetics, pharmaceutical databases.