What is the GHS hazard classification for Phosphoric acid?
Phosphoric acid (CAS 7664-38-2) is classified under EU CLP Annex VI as Skin Corr. 1B with signal word Danger. Hazard statements: H314. Source: EU CLP Annex VI (ECHA).
Danger
GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Phosphoric acid
Also known as: Phosphoric acid Divosan X-Tend formulation, Caswell No. 662, EINECS 231-633-2, EPA Pesticide Chemical Code 076001, FEMA No. 2900 (+15 more)
CAS 7664-38-2
Phosphoric acid (CAS 7664-38-2) is a chemical substance with GHS signal word Danger; key hazard signal: H314. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Phosphoric acid is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics at max 49%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
44
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Phosphoric acid
CAS Number
7664-38-2
DTXSID
DTXSID5024263
Molecular Formula
H3O4P
InChI Key
NBIIXXVUZAFLBC-UHFFFAOYSA-N
Monoisotopic Mass
97.976896
Synonyms
Phosphoric acid Divosan X-Tend formulationCaswell No. 662EINECS 231-633-2EPA Pesticide Chemical Code 076001FEMA No. 2900o-Phosphoric acidPhosphoric acid, ortho-Acido fosforicoFosforzuuroplossingenUNII-E4GA8884NNPhosphoricum acidumAcide phosphorique (FRENCH)
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Corr. 1B | H314 | GHS05 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
2 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | May be osive to metals Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life See Notes |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause asthma-like reactions (RADS). Exposure could cause asphyxiation due to swelling in the throat. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. Inhalation of high concentrations may cause pneumonitis. See Notes. |
| Long-term Effects | The substance may have effects on the upper respiratory tract and lungs. This may result in chronic inflammation and reduced lung function . Mists of this strong inorganic acid are carcinogenic to humans. See Notes. |
| Routes of Exposure | Serious local effects by all routes of exposure. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
8 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 1 mg/m³ | - | 1 | N |
| NIOSH | TWA | 1 mg/m³ | - | 1 | N |
| NIOSH | STEL | 3 mg/m³ | - | 3 | N |
| ACGIH | TWA | 1 mg/m³ [1992] | - | 1 | N |
| ACGIH | STEL | 3 mg/m³ [1992] | - | 3 | N |
| CAL/OSHA | TWA | 1 mg/m³ | - | 1 | N |
| CAL/OSHA | STEL | 3 mg/m³ | - | 3 | N |
| NIOSH | IDLH | 1000 mg/m³ | - | 1000 | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Stabilizing agentBleaching agentpH regulating agentFragranceFlux agentFlavouring and nutrientDispersing agentConductive agentSoil amendmentsEtching agentCorrosion inhibitor
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 44 of 44 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4.87800896870356 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 4.35372386880535 | uM | ACC | - | - | NTP_ICE_endocrine |
| =2.25 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =2.25 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =64 | mg/m3 | BMC (05) | inhalation | Rat | ToxValDB_Cal_OEHHA_REL_derivations |
| =3.4 | mg/m3 | BMC (10 HEC) | inhalation | Rat | ToxValDB_IRIS |
| =5.4 | mg/m3 | BMC (10) | inhalation | Rat | ToxValDB_IRIS |
| =100 | mg/m3 | BMC (10) | inhalation | Rat | ToxValDB_IRIS |
| =3.4 | mg/m^3 | BMC 10 (HEC) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| 10.96 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| 240 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| =1 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =2.92 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =10.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| E4GA8884NN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E4GA8884NN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E4GA8884NN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E4GA8884NN | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| 0.0255 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >0.85 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0069 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =0.75 | % diet | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =145.7 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| =282 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =320 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_HPVIS |
| =370 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_HPVIS |
| =410 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =0.01 | mg/m3 | RfC | inhalation | Human | ToxValDB_IRIS |
| =0.01 | mg/m^3 | RfC | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =1 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =4 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =48.6 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
| 1.7 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.3 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 9 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 65.6 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 67.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 113.1 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 9.8 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 20.6 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 20.8 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 44 of 44 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Orthophosphoric acid | 231-633-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
49%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PHOSPHORIC ACID
ChEMBL Phase
4
Adverse Events
108
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Phosphoric acid?
Phosphoric acid has 44 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
What regulatory lists include Phosphoric acid?
Phosphoric acid appears on 11 regulatory/inventory lists including active_ingredient; Europe; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, and 8 more. Source: EPA CPDat.
What are the occupational exposure limits for Phosphoric acid?
Occupational exposure limits for Phosphoric acid are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Phosphoric acid used in cosmetics?
Yes, Phosphoric acid is also indexed as a cosmetic ingredient under the name Phosphoric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phosphoric acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Phosphoric acid have different safety status in cosmetics vs industrial chemicals?
Phosphoric acid is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics at max 49%.
Is Phosphoric acid used outside industrial chemicals?
Phosphoric acid also appears in cosmetics, pharmaceutical, cannabis databases.