Danger GHS07GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Zinc chloride

Also known as: ZnCl2, Zinc Chloride (ZnC!,), Zinc chloride (ZnCl2), Caswell No. 910, EINECS 231-592-0 (+8 more)

CAS 7646-85-7

Zinc chloride (CAS 7646-85-7) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H314; H400; H410. Key regulatory status: REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Zinc Chloride →

SOURCE noael studies public
NOAEL studies
81
SOURCE chemical inventory jurisdictions
Regulatory lists
18
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields
Name
Zinc chloride
CAS Number
7646-85-7
DTXSID
DTXSID2035013
Molecular Formula
2ClH.Zn
InChI Key
JIAARYAFYJHUJI-UHFFFAOYSA-L
Monoisotopic Mass
135.882497
Synonyms
ZnCl2Zinc Chloride (ZnC!,)Zinc chloride (ZnCl2)Caswell No. 910EINECS 231-592-0EPA Pesticide Chemical Code 087801Zine dichlorideZintraceZinc chloride in plastic containerZinkchlorideUNII-86Q357L16Bdichlorozinc

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Skin Corr. 1B; Aquatic Acute 1; Aquatic Chronic 1H302; H314; H400; H410GHS07; GHS05; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsHarmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Very toxic to aquatic life with long lasting effects
Short-term EffectsThe substance is corrosive to the eyes and skin. The aerosol is severely irritating to the respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. Inhalation of high concentrations of respirable particles (such as fumes) may cause Adult Respiratory Distress Syndrome (ARDS), pulmonary fibrosis and death. See Notes.
Routes of ExposureThe substance can be absorbed into the body by inhalation and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 8 records
AgencyMetricValueppmmg/m3Skin
OSHATWA1 mg/m³-1N
NIOSHTWA1 mg/m³-1N
NIOSHSTEL2 mg/m³-2N
ACGIHTWA1 mg/m³ [1992]-1N
ACGIHSTEL2 mg/m³ [1992]-2N
CAL/OSHATWA1 mg/m³-1N
CAL/OSHASTEL2 mg/m³-2N
NIOSHIDLH50 mg/m³-50-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 27 records
Corrosion inhibitorDehydrating agent (desiccant)PharmaceuticalHumectantAstringentBiocideFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 18 records
ListKeywordSource
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
Europe; supplementsEUCPCat
Europe; food_additive; supplementsEUCPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
inert_ingredient; non_food_use; PesticidesEPACPCat
PesticidesNational Park ServiceCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 81 studies
ValueUnitEndpointRouteSpeciesSource
=1mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
86Q357L16BUNIIFDA UNII substance identifier--openFDA substances
86Q357L16BUNIIFDA UNII substance identifier--openFDA substances
86Q357L16BUNIIFDA UNII substance identifier--openFDA substances
86Q357L16BUNIIFDA UNII substance identifier--openFDA substances
1unitlessGHS ClassificationOcularRabbitNTP_ICE_eye_irritation
2mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=0.3mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
>0.5mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=2.5mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=7.5mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=12mg/kg bw/dayLOAELoralRatToxValDB_HPVIS
=2880mg/kg bw/dayLOAELoralRatToxValDB_HPVIS
=5910mg/kg bw/dayLOAELoralMouseToxValDB_HPVIS
=0.00138mol/kg bwLOELoralMouseToxValDB_ECOTOX
=0.01mMLOELinjectionRatToxValDB_ECOTOX
=0.1mmol/kgLOELinjectionMouseToxValDB_ECOTOX
=0.12mg/kg bw/dayLOELinjectionMouseToxValDB_ECOTOX
=0.2mmol/kgLOELinjectionRatToxValDB_ECOTOX
=0.5%LOELoralMouseToxValDB_ECOTOX
=1% w/vLOELdermalMouseToxValDB_ECOTOX
=1mmol/kgLOELinjectionRatToxValDB_ECOTOX
=2mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=4mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=4.6mmolLOELoralRatToxValDB_ECOTOX
=5mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=5.5mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=6.5mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=8mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=13umol/kg/dayLOELinjectionRatToxValDB_ECOTOX
=14mg/kg bw/dayLOELinjectionMouseToxValDB_ECOTOX
=16.5mg/kg bw/dayLOELoralMouseToxValDB_ECOTOX
=20mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=27mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=28mg/kg bw/dayLOELinjectionMouseToxValDB_ECOTOX
=60mg/LLOELoralRatToxValDB_ECOTOX
=100mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=240mg/LLOELoralRatToxValDB_ECOTOX
=400ppmLOELoralRatToxValDB_ECOTOX
=400umol/kg/dayLOELinjectionMouseToxValDB_ECOTOX
=530ppmLOELoralRatToxValDB_ECOTOX
=1000ppmLOELoralRatToxValDB_ECOTOX
=1550ppmLOELoralRatToxValDB_ECOTOX
=10000ppmLOELoralMouseToxValDB_ECOTOX
=12.5mg/kg bw/dayNOAELinjectionMouseToxValDB_HPVIS
=15mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
25mg/kg bw/dayNOAELoralratCOSMOS_DB
28mg/kg bw/dayNOAELoralratCOSMOS_DB
125mg/kg bw/dayNOAELoralratCOSMOS_DB
150mg/kg bw/dayNOAELoralmouseCOSMOS_DB

Showing 50 of 81 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredZinc chloride231-592-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
1%
Category
Skin Conditioning
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL ZINC CHLORIDE
ChEMBL Phase
4
Adverse Events
174
Bioactivity
14
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Zinc chloride?

Zinc chloride (CAS 7646-85-7) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Corr. 1B; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H302; H314; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Zinc chloride?

Zinc chloride has 81 NOAEL studies in the database. The lowest reported value is 0.00138 mol/kg bw via oral in Mouse. Source: ToxValDB_ECOTOX.

What regulatory lists include Zinc chloride?

Zinc chloride appears on 9 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 6 more. Source: EPA CPDat.

What are the occupational exposure limits for Zinc chloride?

Occupational exposure limits for Zinc chloride are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Zinc chloride used in cosmetics?

Yes, Zinc chloride is also indexed as a cosmetic ingredient under the name Zinc Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Zinc chloride come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Zinc chloride have different safety status in cosmetics vs industrial chemicals?

Zinc chloride is classified GHS Danger (H302, H314, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 1%.

Is Zinc chloride used outside industrial chemicals?

Zinc chloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.