Also known as: Cobaltous chloride, Cobalt chloride,, COBALT (II) CHLORIDE, Cobalt chloride (CoCl2), EINECS 231-589-4 (+5 more)
CAS 7646-79-9
Cobalt chloride (CAS 7646-79-9) is a chemical substance with GHS signal word Danger; key hazard signal: H350i; H341; H360F ***; H302; H334; H317; H400; H410. Key regulatory status: SVHC Candidate List, REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC, ILO ICSC.
Cobalt chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H350i, H341, H360F, H302, H334, H317, H400, H410).
CAS, identifiers, formula, and alternate names for the matched substance record.
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| Cobalt dichloride | Carcinogenic (Article 57a); Toxic for reproduction (Article 57c) | 28-Oct-2008 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 4 *; Resp. Sens. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 | H350i; H341; H360F ***; H302; H334; H317; H400; H410 | GHS08; GHS07; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Harmful if swallowed May be harmful in contact with skin Causes eye irritation May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause an allergic skin reaction May cause cancer if inhaled Suspected of causing genetic defects May damage fertility or the unborn child May cause damage to thyroid, bone marrow and heart through prolonged or repeated exposure if swallowed Very toxic to aquatic life with long lasting effects |
| Short-term Effects | The substance is irritating to the eyes. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. Ingestion may cause effects on the heart, bone marrow and thyroid. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| banned; Europe; Personal care | European Commission | CosIng |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 35.5 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 9.478 | ug/mL | CD86, EC120 | Dermal | - | NTP_ICE_skin_sensitization |
| 208.3 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =0.0881 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 30.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 35 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| <241.13 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 298.6 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.4 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.6 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.8 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.8 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.8 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 0.8 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| EVS87XF13W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EVS87XF13W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EVS87XF13W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EVS87XF13W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >600 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1330.2 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 7.479 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 23.3 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =4 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| =250 | umol/kg bw | LOEL | injection | Rat | ToxValDB_ECOTOX |
| 7.2 | ratio | Max stimulation index | Dermal | Mouse | NTP_ICE_skin_sensitization |
| =3 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =25 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =180 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_HPVIS |
Showing 32 of 32 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cobalt dichloride | 231-589-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Cobalt chloride (CAS 7646-79-9) is classified under EU CLP Annex VI as Carc. 1B; Muta. 2; Repr. 1B; Acute Tox. 4 *; Resp. Sens. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H350i; H341; H360F ***; H302; H334; H317; H400; H410. Source: EU CLP Annex VI (ECHA).
Cobalt chloride has 32 NOAEL studies in the database. The lowest reported value is 0.0881 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Cobalt chloride appears on 5 regulatory/inventory lists including Canada; pharmaceutical, Canada; consumer_product; Substances in Products - Canada (4/2014), active_ingredient; animal_products; Europe; pharmaceutical; residue, and 2 more. Source: EPA CPDat.
Yes, Cobalt chloride is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Carcinogenic (Article 57a); Toxic for reproduction (Article 57c). Source: ECHA SVHC Candidate List.
Yes, Cobalt chloride is also indexed as a cosmetic ingredient under the name Cobalt Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, ILO/WHO ICSC, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Cobalt chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H350i, H341, H360F, H302, H334, H317, H400, H410).
Cobalt chloride also appears in cosmetics, food safety databases.