Danger GHS03GHS06GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Sodium nitrite

Also known as: Nitrous acid, sodium salt, Anti-Rust, Nitrous Acid Soda, Caswell No. 782, Diazotizing salts (+10 more)

CAS 7632-00-0

Sodium nitrite (CAS 7632-00-0) is a chemical substance with GHS signal word Danger; key hazard signal: H272; H301; H400. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, EPA TRI.

View cosmetic safety profile for Sodium Nitrite →

SOURCE NOAEL studies
NOAEL studies
100
SOURCE Chemical inventory jurisdictions
Regulatory lists
13
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields
Name
Sodium nitrite
CAS Number
7632-00-0
DTXSID
DTXSID0020941
Molecular Formula
HNO2.Na
InChI Key
LPXPTNMVRIOKMN-UHFFFAOYSA-M
Synonyms
Nitrous acid, sodium saltAnti-RustNitrous Acid SodaCaswell No. 782Diazotizing saltsEINECS 231-555-9EPA Pesticide Chemical Code 076204NCI-C02084NSC 77391Azotyn sodowyDusitan sodnyUNII-M0KG633D4F

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Ox. Sol. 3; Acute Tox. 3 *; Aquatic Acute 1H272; H301; H400GHS03; GHS06; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes. The substance may cause effects on the cardiovascular system and blood. This may result in lower blood pressure and the formation of methaemoglobin. Exposure could cause death. The effects may be delayed. Medical observation is indicated.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Corrosion inhibitorPharmaceuticalFood preservativeBiocideProcessing aids not otherwise specifiedPreservativepH regulating agentPropellants, non-motive (blowing agents)Flavouring and nutrientAntioxidantDye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 13 records
ListKeywordSource
Cleaning products and household care - shoes; EuropeDanish Environmental Protection AgencyDanish EPA
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
Cleaning products and household care - shoes; EuropeDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
Europe; Vehicle - car interiorDanish Environmental Protection AgencyDanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
=0.06mg/kg bw/dayADI--WHO/JECFA
=0.06mg/kg bw/dayADI--WHO/JECFA
=0.07mg/kg bw/dayADI-RatWHO/JECFA
=0.07mg/kg bw/dayADI-RatWHO/JECFA
=0.1mg/kg bw/dayADI-ConsumersEFSA
=0.1mg/kg bw/dayADI-ConsumersEFSA
=0.2mg/kg bw/dayADI--WHO/JECFA
=0.2mg/kg bw/dayADI--WHO/JECFA
=0.4mg/kg bw/dayADI--WHO/JECFA
=0.4mg/kg bw/dayADI--WHO/JECFA
=100mg/kg bw/dayADI-RatWHO/JECFA
=100mg/kg bw/dayADI-RatWHO/JECFA
=9.63mg/kg bw/dayBMDLoralRatEFSA
=2mg/m3DNEL systemicinhalationHumanToxValDB GESTIS DNEL
M0KG633D4FUNIIFDA UNII substance identifier--openFDA substances
M0KG633D4FUNIIFDA UNII substance identifier--openFDA substances
M0KG633D4FUNIIFDA UNII substance identifier--openFDA substances
M0KG633D4FUNIIFDA UNII substance identifier--openFDA substances
0.0055mg/LLC50Inhalation-NTP ICE acute inhalation
=30mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=35mg/kg bw/dayLELoralRatToxValDB ToxRefDB
=35mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=40mg/kg bw/dayLELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=45mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=45mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=60mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=60mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=345mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=345mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=445mg/kg bw/dayLELoralMouseToxValDB ToxRefDB
=445mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=130mg/kg bw/dayLOAELoralRatToxValDB ToxRefDB
=130mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=150mg/kg bw/dayLOAELoralRatToxValDB ToxRefDB
=150mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=165mg/kg bw/dayLOAELoralMouseToxValDB ToxRefDB
=165mg/kg bw/dayLOAELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=220mg/kg bw/dayLOAELoralMouseToxValDB ToxRefDB
=220mg/kg bw/dayLOAELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=990mg/kg bw/dayLOAELoralMouseToxValDB ToxRefDB
=990mg/kg bw/dayLOAELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=1230mg/kg bw/dayLOAELoralMouseToxValDB ToxRefDB
=1230mg/kg bw/dayLOAELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
-unitlessModel Score--NTP ICE endocrine
>-mg/kg bw/dayNELoralrat (fischer; Fischer 344)EPA ToxRefDB v3
=190mg/kg bw/dayNELoralMouseToxValDB ToxRefDB
=190mg/kg bw/dayNELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
=240mg/kg bw/dayNELoralMouseToxValDB ToxRefDB
=240mg/kg bw/dayNELoralmouse (b6c3f1; B6C3F1)EPA ToxRefDB v3
5mg/kg bw/dayNOAELoralmouseCOSMOS DB

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records
StatusNameEC NumberLink
RegisteredSodium nitrite231-555-9ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Sodium nitrite--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed SODIUM NITRITE
ChEMBL Phase
4
Adverse Events
4
Bioactivity
6
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Sodium nitrite?

Sodium nitrite (CAS 7632-00-0) is classified under EU CLP Annex VI as Ox. Sol. 3; Acute Tox. 3 *; Aquatic Acute 1 with signal word Danger. Hazard statements: H272; H301; H400. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Sodium nitrite?

Sodium nitrite has 100 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include Sodium nitrite?

Sodium nitrite appears on 9 regulatory/inventory lists including Cleaning products and household care - shoes; Europe, Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides, and 6 more. Source: EPA CPDat.

Is Sodium nitrite used in cosmetics?

Yes, Sodium nitrite is also indexed as a cosmetic ingredient under the name Sodium Nitrite. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sodium nitrite come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Sodium nitrite have different safety status in cosmetics vs industrial chemicals?

Sodium nitrite is classified GHS Danger (H272, H301, H400) in the chemicals database but is restricted in EU cosmetics.

Is Sodium nitrite used outside industrial chemicals?

Sodium nitrite also appears in cosmetics, pharmaceutical, cannabis databases.