Danger GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

Trifluoroacetic acid

Also known as: 2,2,2-Trifluoroacetic acid, Acetic acid, 2,2,2-trifluoro-, Perfluoroacetic acid, Trifluoroethanoic acid, Perfluoro-n-ethanoic acid (+10 more)

CAS 76-05-1

Trifluoroacetic acid (CAS 76-05-1) is a chemical substance with GHS signal word Danger; key hazard signal: H332; H314; H412. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Trifluoroacetic Acid (TFA) →

Cross-Vertical Regulatory Divergence

Trifluoroacetic acid is classified GHS Danger (H332, H314, H412) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 21 fields

Name

Trifluoroacetic acid

CAS Number

76-05-1

DTXSID

DTXSID9041578

Molecular Formula

C2HF3O2

InChI Key

DTQVDTLACAAQTR-UHFFFAOYSA-N

Monoisotopic Mass

113.992864

Synonyms

2,2,2-Trifluoroacetic acidAcetic acid, 2,2,2-trifluoro-Perfluoroacetic acidTrifluoroethanoic acidPerfluoro-n-ethanoic acidAcetic acid, trifluoro-NSC 77366UN 26994-02-00-00458BRN 0742035EINECS 200-929-3Kyselina trifluoroctova

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 *; Skin Corr. 1A; Aquatic Chronic 3	H332; H314; H412	GHS07; GHS05	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Causes severe skin burns and eye damage Causes damage to respiratory tract if inhaled Harmful to aquatic life
Short-term Effects	The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of fumes may cause lung oedema. See Notes.
Routes of Exposure	Serious local effects by all routes of exposure.

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 39 of 39 studies

Value	Unit	Endpoint	Route	Species	Source
=0.05	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.05	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.05	mg/kg bw/day	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=0.05	mg/kg bw/day	ARfD	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
4.5	min	Breakthrough Time	Dermal	-	NTP_ICE_skin_irritation
=2.67	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
E5R8Z4G708	UNII	FDA UNII substance identifier	-	-	openFDA substances
E5R8Z4G708	UNII	FDA UNII substance identifier	-	-	openFDA substances
E5R8Z4G708	UNII	FDA UNII substance identifier	-	-	openFDA substances
E5R8Z4G708	UNII	FDA UNII substance identifier	-	-	openFDA substances
10	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=200	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
~300	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
>=327.7	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
<=344.1	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=500	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
=37	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_PFAS_150_SEM_v2
=112.5	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_PFAS_150_SEM_v2
=153.6	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_PFAS_150_SEM_v2
=9.9	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=9.9	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=9.9	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=10	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=10	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=10	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=15.36	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_PFAS_150_SEM_v2
=25	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=37.5	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_PFAS_150_SEM_v2
=43	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=43	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=43	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=75	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_PFAS_150_SEM_v2
=150	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=375	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_PFAS_150_SEM_v2
=1536	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_PFAS_150_SEM_v2
=98	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_EFSA
=98	mg/kg bw/day	NOEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=98	mg/kg bw/day	NOEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=1000	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 39 of 39 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Trifluoroacetic acid	200-929-3	ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL TRIFLUOROACETIC ACID

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Trifluoroacetic acid?

Trifluoroacetic acid (CAS 76-05-1) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Corr. 1A; Aquatic Chronic 3 with signal word Danger. Hazard statements: H332; H314; H412. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Trifluoroacetic acid?

Trifluoroacetic acid has 39 NOAEL studies in the database. The lowest reported value is 0.05 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.

Is Trifluoroacetic acid used in cosmetics?

Yes, Trifluoroacetic acid is also indexed as a cosmetic ingredient under the name Trifluoroacetic Acid (TFA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Trifluoroacetic acid come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Trifluoroacetic acid have different safety status in cosmetics vs industrial chemicals?

Trifluoroacetic acid is classified GHS Danger (H332, H314, H412) in the chemicals database but is allowed in EU cosmetics.

Is Trifluoroacetic acid used outside industrial chemicals?

Trifluoroacetic acid also appears in cosmetics, pharmaceutical, cannabis databases.