What is the NOAEL for 1-Chloro-1,1-difluoroethane?
1-Chloro-1,1-difluoroethane has 16 NOAEL studies in the database. The lowest reported value is FUC3XHA6GY UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Chloro-1,1-difluoroethane
Also known as: HCFC-142b, BRN 1731584, Chloroethylidene fluoride, Difluoro-1-chloroethane, EINECS 200-891-8 (+6 more)
CAS 75-68-3
1-Chloro-1,1-difluoroethane (CAS 75-68-3) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, EPA TRI.
View cosmetic safety profile for Hydrochlorofluorocarbon 142b (HCFC-142b) →
Cross-Vertical Regulatory Divergence
1-Chloro-1,1-difluoroethane is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H280, H420, H320, H335, H336, H402, H412).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
1-Chloro-1,1-difluoroethane
CAS Number
75-68-3
DTXSID
DTXSID9023960
Molecular Formula
C2H3ClF2
InChI Key
BHNZEZWIUMJCGF-UHFFFAOYSA-N
Monoisotopic Mass
99.989134
Synonyms
HCFC-142bBRN 1731584Chloroethylidene fluorideDifluoro-1-chloroethaneEINECS 200-891-8Fluorocarbon 142bFluorocarbon FC142bGentron 142bIsotron 142bMonochlorodifluoroethaneUNII-FUC3XHA6GY
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Propellants, non-motive (blowing agents)DeodorizerFoamant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| FUC3XHA6GY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FUC3XHA6GY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FUC3XHA6GY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FUC3XHA6GY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2050 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =254823 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| >38716.6 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >38716.6 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >41100.4 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >82200.8 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =82620 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_IRIS |
| =14710 | mg/m3 | NOAEL (ADJ) | inhalation | Rat | ToxValDB_IRIS |
| =14710 | mg/m^3 | NOAEL (HEC) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =50 | mg/m3 | RfC | inhalation | Human | ToxValDB_IRIS |
| =50 | mg/m^3 | RfC | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =14 | mg/kg bw/day | RfD | oral | Human | ToxValDB_NJ_DEP |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-chloro-1,1-difluoroethane | 200-891-8 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| 1-Chloro-1,1-difluoroethane (HCFC-142b) | - | - |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
What regulatory lists include 1-Chloro-1,1-difluoroethane?
1-Chloro-1,1-difluoroethane appears on 1 regulatory/inventory list including inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is 1-Chloro-1,1-difluoroethane used in cosmetics?
Yes, 1-Chloro-1,1-difluoroethane is also indexed as a cosmetic ingredient under the name Hydrochlorofluorocarbon 142b (HCFC-142b). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Chloro-1,1-difluoroethane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Chloro-1,1-difluoroethane have different safety status in cosmetics vs industrial chemicals?
1-Chloro-1,1-difluoroethane is prohibited in EU cosmetics but has active industrial GHS classifications (H220, H280, H420, H320, H335, H336, H402, H412).
Is 1-Chloro-1,1-difluoroethane used outside industrial chemicals?
1-Chloro-1,1-difluoroethane also appears in cosmetics databases.