What is the NOAEL for Tetramethylammonium chloride?
Tetramethylammonium chloride has 6 NOAEL studies in the database. The lowest reported value is 2.9 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tetramethylammonium chloride
Also known as: methanaminium, N,N,N-trimethyl-, chloride, EINECS 200-880-8, UNII-DCQ9S88703
CAS 75-57-0
Tetramethylammonium chloride (CAS 75-57-0) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
View cosmetic safety profile for Tetramethylammonium Chloride →
Cross-Vertical Regulatory Divergence
Tetramethylammonium chloride is classified GHS Danger (H300, H301, H311, H315, H319, H335, H370, H411) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
Tetramethylammonium chloride
CAS Number
75-57-0
DTXSID
DTXSID6021749
Molecular Formula
C4H12N.ClH
InChI Key
OKIZCWYLBDKLSU-UHFFFAOYSA-M
Monoisotopic Mass
110.073652
Synonyms
methanaminium, N,N,N-trimethyl-, chlorideEINECS 200-880-8UNII-DCQ9S88703
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
Viscosity modifierStabilizing agentCatalyst
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| fracking | FracFocus | FracFocus |
| fracking; water | NY Department of Conservation | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| DCQ9S88703 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DCQ9S88703 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DCQ9S88703 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| DCQ9S88703 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tetramethylammonium chloride | 200-880-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Rheology Modifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TETRAMETHYLAMMONIUM
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Tetramethylammonium chloride?
Tetramethylammonium chloride appears on 2 regulatory/inventory lists including fracking, fracking; water. Source: EPA CPDat.
Is Tetramethylammonium chloride used in cosmetics?
Yes, Tetramethylammonium chloride is also indexed as a cosmetic ingredient under the name Tetramethylammonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tetramethylammonium chloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Tetramethylammonium chloride have different safety status in cosmetics vs industrial chemicals?
Tetramethylammonium chloride is classified GHS Danger (H300, H301, H311, H315, H319, H335, H370, H411) in the chemicals database but is allowed in EU cosmetics.
Is Tetramethylammonium chloride used outside industrial chemicals?
Tetramethylammonium chloride also appears in cosmetics, pharmaceutical databases.