Also known as: 2-Propanamine, EINECS 200-860-9, Propanal, 2-amino-, 2-Amino-propaan, 2-Aminopropan (+3 more)
CAS 75-31-0
Isopropylamine (CAS 75-31-0) is a chemical substance with GHS signal word Danger; key hazard signal: H224; H335; H315; H319. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
Isopropylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H224, H335, H315, H319).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 1; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2 | H224; H335; H315; H319 | GHS02; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Extremely flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage Causes damage to respiratory tract May be harmful if swallowed and enters airways Harmful to aquatic life |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. Exposure above the OEL could cause death. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. |
| Routes of Exposure | Serious local effects by all routes of exposure. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 ppm (12 mg/m³) | 5 | 12 | N |
| ACGIH | TWA | 5 ppm [1962] | 5 | - | N |
| ACGIH | STEL | 10 ppm [1962] | 10 | - | N |
| CAL/OSHA | TWA | 5 ppm (12 mg/m³) | 5 | 12 | N |
| CAL/OSHA | STEL | 10 ppm (24 mg/m³) | 10 | 24 | N |
| NIOSH | IDLH | 750 ppm | 750 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =12 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =10 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| P8W26T4MTD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8W26T4MTD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8W26T4MTD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8W26T4MTD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7.7 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 8.5532 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 8.7 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 9.4 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 9.6647 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 11.5251 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 16.7199 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 43.9742 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =48353.6 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =500 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
Showing 16 of 16 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isopropylamine | 200-860-9 | ECHA overview → |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Isopropylamine (CAS 75-31-0) is classified under EU CLP Annex VI as Flam. Liq. 1; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2 with signal word Danger. Hazard statements: H224; H335; H315; H319. Source: EU CLP Annex VI (ECHA).
Isopropylamine has 16 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Isopropylamine appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Pesticides, Europe, and 1 more. Source: EPA CPDat.
Occupational exposure limits for Isopropylamine are set by OSHA, ACGIH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Isopropylamine is also indexed as a cosmetic ingredient under the name Isopropylamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Isopropylamine is prohibited in EU cosmetics but has active industrial GHS classifications (H224, H335, H315, H319).
Isopropylamine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.