What is the NOAEL for Isobutane?
Isobutane has 17 NOAEL studies in the database. The lowest reported value is BXR49TP611 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Isobutane
Also known as: 2-Methylpropane, Caswell No. 503A, EINECS 200-857-2, EPA Pesticide Chemical Code 097101, UNII-BXR49TP611 (+3 more)
CAS 75-28-5
Isobutane (CAS 75-28-5) is a chemical substance. Key regulatory status: REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Isobutane is classified GHS Danger (H220, H280, H332, H336, H371, H340, H350) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
17
SOURCE
Chemical inventory jurisdictions
Regulatory lists
18
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Isobutane
CAS Number
75-28-5
DTXSID
DTXSID1026401
Molecular Formula
C4H10
InChI Key
NNPPMTNAJDCUHE-UHFFFAOYSA-N
Monoisotopic Mass
58.07825
Synonyms
2-MethylpropaneCaswell No. 503AEINECS 200-857-2EPA Pesticide Chemical Code 097101UNII-BXR49TP611(CH3)2CH-CH3E943bR-600a
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | Rapid evaporation of the liquid may cause frostbite. The substance may cause effects on the cardiovascular system. This may result in impaired functions and respiratory failure. Exposure at high levels could cause death. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
2 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 800 ppm (1900 mg/m³) | 800 | 1900 | N |
| ACGIH | STEL | 1000 ppm [2012] | 1000 | - | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Propellants, non-motive (blowing agents)No specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
18 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| BXR49TP611 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BXR49TP611 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BXR49TP611 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| BXR49TP611 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 658 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 1354.1951 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 1354.944 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 1355 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =42790.9 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| >166409 | mg/m3 | LEL | inhalation | Dog | ECHA |
| =475454 | mg/m3 | LEL | inhalation | Rat | ECHA |
| =642000 | mg/m3 | LEL | inhalation | Rat | ECHA |
| =21395.4 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB HPVIS |
| =21394 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| =21395.4 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| =1000 | ppm | NOAEL | - | Human | ToxValDB TX TCEQ |
| =2377.27 | mg/m3 | NOAEL | inhalation | Human | ToxValDB TX TCEQ |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isobutane | 200-857-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
ISOBUTANE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Isobutane?
Isobutane appears on 15 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Arts and crafts/Office supplies - general arts and crafts supplies; Europe, Cleaning products and household care - shoes; Europe, and 12 more. Source: EPA CPDat.
What are the occupational exposure limits for Isobutane?
Occupational exposure limits for Isobutane are set by NIOSH, ACGIH. 2 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Isobutane used in cosmetics?
Yes, Isobutane is also indexed as a cosmetic ingredient under the name Isobutane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isobutane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Isobutane have different safety status in cosmetics vs industrial chemicals?
Isobutane is classified GHS Danger (H220, H280, H332, H336, H371, H340, H350) in the chemicals database but is allowed in EU cosmetics.
Is Isobutane used outside industrial chemicals?
Isobutane also appears in cosmetics, pharmaceutical, cannabis databases.