Warning GHS08 NOAEL Data IARC Group 2A Prop 65 REACH Registered Cosmetic Ingredient

Dichloromethane

Also known as: Methane, dichloro-, Methylene chloride, 4-01-00-00035, BRN 1730800, Caswell No. 568 (+15 more)

CAS 75-09-2

Dichloromethane (CAS 75-09-2) is a chemical substance with GHS signal word Warning; key hazard signal: H351. Key regulatory status: California Proposition 65, REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Methylene Chloride →

Cross-Vertical Regulatory Divergence

Dichloromethane is prohibited in EU cosmetics but has active industrial GHS classifications (H351).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Dichloromethane

CAS Number

75-09-2

DTXSID

DTXSID0020868

Molecular Formula

CH2Cl2

InChI Key

YMWUJEATGCHHMB-UHFFFAOYSA-N

Monoisotopic Mass

83.953355

Synonyms

Methane, dichloro-Methylene chloride4-01-00-00035BRN 1730800Caswell No. 568EINECS 200-838-9EPA Pesticide Chemical Code 042004Methylenum chloratumNCI-C50102RCRA waste number U080UNII-588X2YUY0AAerothene

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 2A	Probably carcinogenic	2014	Sup 7, 71, 110

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records

Chemical	Toxicity Type	Cancer	Developmental	Listed
-	cancer	Yes	No	-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Carc. 2	H351	GHS08	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Harmful if swallowed Fatal if inhaled Causes skin and eye irritation May cause drowsiness or dizziness Causes damage to central nervous system, blood, liver, the heart and lungs May be harmful if swallowed and enters airways Causes damage to the central nervous system through prolonged or repeated exposure if inhaled May cause cancer
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system, blood, liver, heart and lungs. Exposure could cause carbon monoxide poisoning. This may result in impaired functions. Exposure at high concentrations could cause lowering of consciousness and death. The effects may be delayed.
Long-term Effects	The substance may have effects on the central nervous system. This substance is probably carcinogenic to humans.
Routes of Exposure	The substance can be absorbed into the body by inhalation, by ingestion and through the skin.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 9 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	25 ppm [12.5 ppm Action Level]	25	-	Y
OSHA	STEL	125 ppm	125	-	Y
ACGIH	TWA	50 ppm [1997]	50	-	N
CAL/OSHA	TWA	25 ppm (87 mg/m³)	25	87	N
CAL/OSHA	STEL	125 ppm (435 mg/m³)	125	435	N
NIOSH	IDLH	2300 ppm	2300	-	-
AIHA	ERPG-1	300 ppm	300	-	-
AIHA	ERPG-2	750 ppm	750	-	-
AIHA	ERPG-3	4000 ppm	4000	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 11 records

SolventAdhesion/cohesion promoterFlavouring and nutrientDye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 23 records

List	Keyword	Source
air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List
banned; Europe; Personal care	European Commission	CosIng
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - fabric treatment and dye; detected	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe	Danish Environmental Protection Agency	Danish EPA
CEDI	FDA	United States Food and Drug Administration (FDA)
consumer_product; detected	Elsevier	CPCat
consumer_product; Europe; nondetect	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Personal care	Elsevier	CPCat
air; detected; emissions; Packaging (non-food contact)	Reproductive Toxicology	Published Articles
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
children; WA Children's Safe Product Act (4/2020)	State of Washington Department of Ecology	State of Washington
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
children	Vermont Department of Health	State of Vermont
children	Oregon Health Authority	State of Oregon

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
=17.2	mg/m3	BMDL (HEC)	inhalation	Rat	ToxValDB_IRIS
=0.19	mg/kg bw/day	BMDL (HED)	oral	Rat	ToxValDB_IRIS
=17.2	mg/m^3	BMDL 10 (HEC)	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=0.19	mg/kg/day	BMDL 10 (HED)	oral	-	EPA_IRIS_iris_rfd_systems.csv
SQEinhalation=200	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
SQEinhalation=200	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
SQEinhalation=200	ug/day	California Proposition 65 NSRL	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
SQEcancer	listing type	California Proposition 65 listing	-	-	California Proposition 65
13.72	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
74.39	uL/min/10^6 cells	Clint	-	Rat	NTP_ICE_adme_parameters
=176	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
588X2YUY0A	UNII	FDA UNII substance identifier	-	-	openFDA substances
588X2YUY0A	UNII	FDA UNII substance identifier	-	-	openFDA substances
588X2YUY0A	UNII	FDA UNII substance identifier	-	-	openFDA substances
588X2YUY0A	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.3875	fraction	Fu	-	Rat	NTP_ICE_adme_parameters
0.7057	fraction	Fu	-	Human	NTP_ICE_adme_parameters
2A	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
2	unitless	IARC group	-	-	NTP_ICE_cancer
1e-8	ug/m3	Inhalation risk unit	Inhalation	-	NTP_ICE_cancer
52	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
52.0441	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
74.744	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
76	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
197.8731	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=500	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_EPA_TSCA_8e
=1000	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_EPA_TSCA_8e
=1500	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_EPA_TSCA_8e
=2000	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_EPA_TSCA_8e
=8684.09	mg/m3	LEL	inhalation	Dog	ToxValDB_EPA_TSCA_8e
=451573	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=3473.64	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=17700	mg/m3	LOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=0.3	mg/kg bw/day	LOAEL	oral: unspecified	Common quail	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=0.3	mg/kg bw/day	LOAEL	oral: unspecified	Common quail	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=0.6	mg/kg bw/day	LOAEL	oral: feed	Black duck	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=0.6	mg/kg bw/day	LOAEL	oral: feed	Black duck	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=16	mg/kg bw/day	LOAEL	oral	Human	ToxValDB_ATSDR_MRLs
=16	mg/kg/day	LOAEL	oral	Human (M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
50	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=50	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_DOE_Wildlife_Benchmarks
55	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=64	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=86.8409	mg/m3	LOAEL	inhalation	Rat (Not Specified; unknown)	ATSDR_toxval_ATSDR_MRLs.xlsx
=138.945	mg/m3	LOAEL	inhalation	Human	ToxValDB_Cal_OEHHA_REL_derivations
250	mg/kg bw/day	LOAEL	oral	mouse	COSMOS_DB
=320	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=677.359	mg/m3	LOAEL	inhalation	Human	ToxValDB_Cal_OEHHA_REL_derivations

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	dichloromethane; methylene chloride	200-838-9	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Dichloromethane (Methylene chloride)	-	-

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1547/15	28 October 2015	not safe (hair sprays)	0.2% maximum impurity; 35% in hair sprays NOT safe	CMR category 2; carcinogenic by inhalation in mice; inadequate data on neurobehavioural and neurodevelopmental effects after short-term exposure by hair spraying; no new data provided in Submission IV
SCCS/1488/12	11 December 2012	not safe (hair sprays at 35%)	35% in hair sprays not safe	CMR 2 carcinogen by inhalation; inadequate neurobehavioural/neurodevelopmental data for short-term inhalation exposure; neurotoxicity concerns

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL METHYLENE CHLORIDE

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Dichloromethane?

Dichloromethane (CAS 75-09-2) is classified under EU CLP Annex VI as Carc. 2 with signal word Warning. Hazard statements: H351. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Dichloromethane?

Dichloromethane has 100 NOAEL studies in the database. The lowest reported value is 0.05 mg/kg bw/day via oral: feed in Chicken. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.

What regulatory lists include Dichloromethane?

Dichloromethane appears on 19 regulatory/inventory lists including air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe, air; detected; emissions; Europe; Toys and children's products, air; detected; emissions; Europe; Other direct contact consumer goods, and 16 more. Source: EPA CPDat.

Is Dichloromethane a carcinogen according to IARC?

Dichloromethane is classified by IARC as Group 2A — probably carcinogenic to humans (evaluated 2014). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Dichloromethane on the California Proposition 65 list?

Yes, Dichloromethane is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Dichloromethane?

Occupational exposure limits for Dichloromethane are set by OSHA, ACGIH, CAL/OSHA. 9 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Dichloromethane used in cosmetics?

Yes, Dichloromethane is also indexed as a cosmetic ingredient under the name Methylene Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dichloromethane come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Dichloromethane have different safety status in cosmetics vs industrial chemicals?

Dichloromethane is prohibited in EU cosmetics but has active industrial GHS classifications (H351).

Is Dichloromethane used outside industrial chemicals?

Dichloromethane also appears in cosmetics, pharmaceutical, cannabis databases.