NOAEL Data Cosmetic Ingredient

2-Methyl-1-naphthol

Also known as: EINECS 231-265-2, 2-Methyl-alpha-naphthol, NSC 402211, UNII-COU5JQ433I

CAS 7469-77-4

2-Methyl-1-naphthol (CAS 7469-77-4) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for 2-Methyl-1-Naphthol →

Cross-Vertical Regulatory Divergence

2-Methyl-1-naphthol is classified GHS Danger (H315, H318, H335) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields

Name

2-Methyl-1-naphthol

CAS Number

7469-77-4

DTXSID

DTXSID50225665

Molecular Formula

C11H10O

InChI Key

SRJCJJKWVSSELL-UHFFFAOYSA-N

Monoisotopic Mass

158.073165

Synonyms

EINECS 231-265-22-Methyl-alpha-naphtholNSC 402211UNII-COU5JQ433I

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 41 of 41 studies

Value	Unit	Endpoint	Route	Species	Source
COU5JQ433I	UNII	FDA UNII substance identifier	-	-	openFDA substances
COU5JQ433I	UNII	FDA UNII substance identifier	-	-	openFDA substances
COU5JQ433I	UNII	FDA UNII substance identifier	-	-	openFDA substances
COU5JQ433I	UNII	FDA UNII substance identifier	-	-	openFDA substances
225	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=0.07	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=0.07	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=0.07	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=0.07	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
75	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=75	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=75	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=75	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=75	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=75	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=75	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=75	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=75	mg/kg bw	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=225	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=225	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=225	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=225	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=500	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=500	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=500	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=500	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=0.07	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=75	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=75	mg/kg bw	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
75	mg/kg bw/day	developmental toxicity	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
75	mg/kg bw/day	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
100	mg/kg bw/day	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
225	mg/kg bw/day	developmental toxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
225	mg/kg bw/day	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
500	mg/kg bw/day	developmental toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
100	mg/kg bw/day	genotoxicity	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
500	mg/kg bw/day	repeated dose toxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 41 of 41 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

2.0%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL122451

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Methyl-1-naphthol?

2-Methyl-1-naphthol has 41 NOAEL studies in the database. The lowest reported value is COU5JQ433I UNII. Source: openFDA substances.

What regulatory lists include 2-Methyl-1-naphthol?

2-Methyl-1-naphthol appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 2-Methyl-1-naphthol used in cosmetics?

Yes, 2-Methyl-1-naphthol is also indexed as a cosmetic ingredient under the name 2-Methyl-1-Naphthol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Methyl-1-naphthol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Methyl-1-naphthol have different safety status in cosmetics vs industrial chemicals?

2-Methyl-1-naphthol is classified GHS Danger (H315, H318, H335) in the chemicals database but is restricted in EU cosmetics at max 2.0%.

Is 2-Methyl-1-naphthol used outside industrial chemicals?

2-Methyl-1-naphthol also appears in cosmetics, pharmaceutical databases.