Danger GHS02GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Zinc

Also known as: Zn, EINECS 231-175-3, Emanay zinc dust, Granular zinc, UNII-J41CSQ7QDS (+11 more)

CAS 7440-66-6

Zinc (CAS 7440-66-6) is a chemical substance with GHS signal word Danger; key hazard signal: H250; H260; H400; H410. Key regulatory status: REACH registered, 52 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, EPA TRI.

View cosmetic safety profile for ZINC →

SOURCE noael studies public
NOAEL studies
53
SOURCE chemical inventory jurisdictions
Regulatory lists
52
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields
Name
Zinc
CAS Number
7440-66-6
DTXSID
DTXSID7035012
Molecular Formula
Zn
InChI Key
HCHKCACWOHOZIP-UHFFFAOYSA-N
Monoisotopic Mass
63.929142
Synonyms
ZnEINECS 231-175-3Emanay zinc dustGranular zincUNII-J41CSQ7QDSZincum metallicum30ZnZinkZn(II)Zn2+cinczincum

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 2 classifications
Hazard ClassH-StatementsPictogramsSignal
Pyr. Sol. 1; Water-react. 1; Aquatic Acute 1; Aquatic Chronic 1H250; H260; H400; H410GHS02; GHS09Danger
Aquatic Acute 1; Aquatic Chronic 1H400; H410GHS09Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsCatches fire spontaneously if exposed to air In contact with water releases flammable gases which may ignite spontaneously Very toxic to aquatic life with long lasting effects
Short-term EffectsMay cause mechanical irritation to the eyes and respiratory tract. Inhalation of the respirable fraction may cause metal fume fever. This may result in influenza-like symptoms. The effects may be delayed up to 48 hours.
Long-term EffectsRepeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged inhalation may cause effects on the lungs. This may result in reduced lung function .
Routes of ExposureThe substance can be absorbed into the body by inhalation.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
AntioxidantDegradant/impurity

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 52 records
ListKeywordSource
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
pharmaceuticalUS International Trade CommissionCPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
Europe; supplementsEUCPCat
detected; emissions; Europe; Other indirect contact consumer goods; waterDanish Environmental Protection AgencyDanish EPA
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
detected; Europe; Personal care - make-up and related - eye linerDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - body paint; detected; EuropeDanish Environmental Protection AgencyDanish EPA
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; EuropeDanish Environmental Protection AgencyDanish EPA
-Journal of Chemical Engineering & Process TechnologyPublished Articles
-Environmental ResearchPublished Articles
detected; drinking_water; MN Chemical ScreeningEPA & USGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPA & USGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPA & USGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningEPA & USGSState of Minnesota
detected; drinking_water; MN Chemical ScreeningUSGSState of Minnesota
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
fracking; waterNY Department of ConservationCPCat
Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
inert_ingredient; PesticidesEPACPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; nondetect; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 53 studies
ValueUnitEndpointRouteSpeciesSource
J41CSQ7QDSUNIIFDA UNII substance identifier--openFDA substances
J41CSQ7QDSUNIIFDA UNII substance identifier--openFDA substances
J41CSQ7QDSUNIIFDA UNII substance identifier--openFDA substances
J41CSQ7QDSUNIIFDA UNII substance identifier--openFDA substances
=0.55mg/m3LOAECinhalationRatToxValDB_ECHA_IUCLID
=4.45mg/m3LOAECinhalationRatToxValDB_ECHA_IUCLID
=0.91mg/kg bw/dayLOAELoralHumanToxValDB_IRIS
=0.91mg/kg/dayLOAELoral-EPA_IRIS_iris_rfd_systems.csv
=53.8mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=60mg/dayLOAELoralHumanToxValDB_Health_Canada
=0.4%LOELoralRatToxValDB_ECOTOX
=0.5%LOELoralRatToxValDB_ECOTOX
=3mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=11.7ppmLOELmultipleRatToxValDB_ECOTOX
=28.8mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=48mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=150ppmLOELoralRatToxValDB_ECOTOX
=350ppmLOELoralRatToxValDB_ECOTOX
=500mg/kg bw/dayLOELoralRatToxValDB_ECOTOX
=900ppmLOELoralRatToxValDB_ECOTOX
=5000mg/kg bw/dayLOELoralMouseToxValDB_ECOTOX
=0.3mg/kg bw/dayMRLoralHumanToxValDB_ATSDR_MRLs
=0.47mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=1.48mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=1.96mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=0.83mg/kg bw/dayNOAELoralHumanToxValDB_ATSDR_MRLs
=0.83mg/kg/dayNOAELoralHuman (F)ATSDR_toxval_ATSDR_MRLs.xlsx
=4.5mg/dayNOAELoralHumanToxValDB_Health_Canada
=31.52mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=40mg/dayNOAELoral: feedHumanEFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
=40mg/dayNOAELoral: feedHumanEFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
=50mg/dayNOAEL-HumanEFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
=50mg/dayNOAEL-HumanEFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
=53mg/dayNOAEL-HumanEFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
=53mg/dayNOAEL-HumanEFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
=220mg/dayNOAELoralHumanToxValDB_WHO_JECFA_Tox_Studies
=600mg/dayNOAELoralHumanToxValDB_WHO_JECFA_Tox_Studies
=0.0018mmolNOELinjectionRatToxValDB_ECOTOX
<0.1mg/gNOELoralMouse; DogINCHEM_WHO_ehc_ehc_ehc221
=0.5%NOELoralRatToxValDB_ECOTOX
=2.3mg/m3NOEL-Guinea pig; PigINCHEM_WHO_ehc_ehc_ehc221
=22.656mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=23.4mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=33.6mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=60ppmNOELoralRatToxValDB_ECOTOX
=100ppmNOELoralRatToxValDB_ECOTOX
=100mg/kg bw/dayNOELoralRatToxValDB_ECOTOX
=100mg/kg bwNOEL-RatINCHEM_WHO_ehc_ehc_ehc221
=200ppmNOELoralMouseToxValDB_ECOTOX
=450ppmNOELoralRatToxValDB_ECOTOX

Showing 50 of 53 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredZinc231-175-3ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Zinc (fume or dust)--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1201279
ChEMBL Phase
Not listed
Adverse Events
3824
Bioactivity
1
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Zinc?

Zinc (CAS 7440-66-6) is classified under EU CLP Annex VI as Pyr. Sol. 1; Water-react. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H250; H260; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Zinc?

Zinc has 53 NOAEL studies in the database. The lowest reported value is J41CSQ7QDS UNII. Source: openFDA substances.

What regulatory lists include Zinc?

Zinc appears on 23 regulatory/inventory lists including active_ingredient; Pesticides, pharmaceutical, Indirect additives food contact (10/2018), and 20 more. Source: EPA CPDat.

Is Zinc used in cosmetics?

Yes, Zinc is also indexed as a cosmetic ingredient under the name ZINC. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Zinc come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Zinc have different safety status in cosmetics vs industrial chemicals?

Zinc is classified GHS Danger (H250, H260, H400, H410) in the chemicals database but is allowed in EU cosmetics.

Is Zinc used outside industrial chemicals?

Zinc also appears in cosmetics, pharmaceutical, food safety, cannabis databases.