Danger GHS02GHS08GHS06GHS09 NOAEL Data IARC Group 1 SVHC REACH Registered

Cadmium

Also known as: C.I. 77180, cadmio, cadmium (non-pyrophoric), CADMIUM (AUSGENOMMEN IN MASSIVER FORM), cadmium (pyrophoric) (+7 more)

CAS 7440-43-9

Cadmium (CAS 7440-43-9) is a chemical substance with GHS signal word Danger; key hazard signal: H250; H350; H341; H361fd; H330; H372 **; H400; H410. Key regulatory status: SVHC Candidate List, REACH registered, 39 regulatory/inventory lists; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ECHA SVHC, ILO ICSC, EPA TRI.

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

Cadmium

CAS Number

7440-43-9

DTXSID

DTXSID1023940

Molecular Formula

InChI Key

BDOSMKKIYDKNTQ-UHFFFAOYSA-N

Monoisotopic Mass

113.903365

Synonyms

C.I. 77180cadmiocadmium (non-pyrophoric)CADMIUM (AUSGENOMMEN IN MASSIVER FORM)cadmium (pyrophoric)UN 2570Colloidal cadmiumEINECS 231-152-8UNII-00BH33GNGH48CdCdKadmium

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 1	Carcinogenic to humans	2009	58, 100C

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA (EU) 1 records

Substance	Reason	Included
Cadmium	Carcinogenic (Article 57a); Specific target organ toxicity after repeated exposure (Article 57(f) - human health)	20-Jun-2013

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Pyr. Sol. 1; Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2 *; STOT RE 1; Aquatic Acute 1; Aquatic Chronic 1	H250; H350; H341; H361fd; H330; H372 **; H400; H410	GHS02; GHS08; GHS06; GHS09	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The fume is irritating to the respiratory tract. Inhalation of fumes may cause lung oedema. See Notes. Inhalation of fumes may cause metal fume fever. The effects may be delayed. Medical observation is indicated.
Long-term Effects	Repeated or prolonged inhalation of dust particles may cause effects on the lungs. The substance may have effects on the kidneys. This may result in kidney impairment. This substance is carcinogenic to humans.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Surface modifierDegradant/impurity

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 39 records

List	Keyword	Source
OEHHA Proposition 65 (3/2019)	STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY	OEHHA Proposition 65 List
detected; Europe; Personal care - make-up and related - eye liner	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - body paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
detected; Israel; Toys and children's products	Chemosphere	Published Articles
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
Canada; pharmaceutical	DrugBank	DrugBank
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Road vehicles	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
detected; Toys and children's products	State of Washington Department of Ecology	State of Washington
Personal care; prohibited; Southeast Asia	Asean	ASEAN Cosmetics
fracking; water	NY Department of Conservation	CPCat
OEHHA Proposition 65 (1/2023)	California Office of Environmental Health Hazard Assessment	OEHHA Proposition 65 List
Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
children	Oregon Health Authority	State of Oregon
consumer_product; Europe	Danish Environmental Protection Agency	Danish EPA
Europe; nondetect; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - body paint - tattoo ink; detected; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Toys and children's products	Environmental Science & Technology	Published Articles
detected; Toys and children's products	Environmental Science & Technology	Published Articles
Arts and crafts/Office supplies - children's art and toys; Arts and crafts/Office supplies - children's art and toys - crayons; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected	Environmental Science & Technology	Published Articles
nondetect; Toys and children's products	Environmental Science & Technology	Published Articles

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 58 studies

Value	Unit	Endpoint	Route	Species	Source
range:0-0.0030.003	mg/kg bw/day	ADI	oral	-	INCHEM_WHO_harmproj_harmproj_harmproj8
=0.05	mg Cd/kg-day	BMDL (1 SD)	oral	Rat	ToxValDB_ATSDR_MRLs
=0.004	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
00BH33GNGH	UNII	FDA UNII substance identifier	-	-	openFDA substances
00BH33GNGH	UNII	FDA UNII substance identifier	-	-	openFDA substances
00BH33GNGH	UNII	FDA UNII substance identifier	-	-	openFDA substances
00BH33GNGH	UNII	FDA UNII substance identifier	-	-	openFDA substances
1	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
1	unitless	IARC group	-	-	NTP_ICE_cancer
0.0018	ug/m3	Inhalation risk unit	Inhalation	-	NTP_ICE_cancer
0.025	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
0.112	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=0.01	mg/m3	LOAEL	inhalation	Rat (F344/N; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.088	mg/m3	LOAEL	inhalation	Rat	ToxValDB_ATSDR_MRLs
=0.088	mg/m3	LOAEL	inhalation	Rat (F344/N; M/F)	ATSDR_toxval_ATSDR_MRLs.xlsx
=0.2	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_MN_MDH_HHBW
=0.01	mg/m3	LOAEL (HEC)	inhalation	Rat	ToxValDB_ATSDR_MRLs
=0.00001	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
=0.00001	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
=0.00003	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
=0.00003	mg/m3	MRL	inhalation	Human	ToxValDB_ATSDR_MRLs
=0.0001	mg/kg bw/day	MRL	oral	Human	ToxValDB_ATSDR_MRLs
=0.0001	mg/kg bw/day	MRL	oral	Human	ToxValDB_ATSDR_MRLs
=0.0005	mg/kg bw/day	MRL	oral	Human	ToxValDB_ATSDR_MRLs
=0.0005	mg/kg bw/day	MRL	oral	Human	ToxValDB_ATSDR_MRLs
=0.005	mg/kg bw/day	NOAEL	oral	Human	ToxValDB_Cal_OEHHA_REL_derivations
=0.005	mg/kg bw/day	NOAEL	oral	Human	ToxValDB_IRIS
=0.005	mg/kg/day	NOAEL	oral	-	EPA_IRIS_iris_rfd_systems.csv
=0.01	mg/kg bw/day	NOAEL	oral	Human	ToxValDB_IRIS
=0.01	mg/L	NOAEL	-	Fish	INCHEM_WHO_ehc_ehc_ehc135
=0.01	mg/kg/day	NOAEL	oral	-	EPA_IRIS_iris_rfd_systems.csv
=0.01	mg/L	NOAEL	-	Fish	INCHEM_WHO_ehc_ehc_ehc135
=0.06	mg/L	NOAEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=0.06	mg/L	NOAEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=1	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_MN_MDH_HHBW
=1.4	mg/m3	NOAEL	inhalation	Human	ToxValDB_Cal_OEHHA_REL_derivations
=2.5	ug Cd/g creatinine in urine	NOAEL	oral	Human	ToxValDB_Health_Canada
=5.2	mg/L	NOAEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=5.2	mg/L	NOAEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=5.24	mg/kg bw/day	NOAEL	oral	Human	ToxValDB_WHO_JECFA_Tox_Studies
=0.001	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=0.001	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=0.0172	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=0.0172	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=0.0536	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=0.0536	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=2.2	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=2.2	mg/L	NOEL	-	-	INCHEM_WHO_ehc_ehc_ehc135
=5.85	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECOTOX
=7.2	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECOTOX

Showing 50 of 58 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Cadmium	231-152-8	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Cadmium	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 2.5 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data cannabis contaminant tests

5 cannabis records found in cannabis contaminant tests (heavy_metal) across Massachusetts.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Cadmium?

Cadmium (CAS 7440-43-9) is classified under EU CLP Annex VI as Pyr. Sol. 1; Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 2 *; STOT RE 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H250; H350; H341; H361fd; H330; H372 **; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Cadmium?

Cadmium has 58 NOAEL studies in the database. The lowest reported value is 0.003 mg/kg bw/day via oral. Source: INCHEM_WHO_harmproj_harmproj_harmproj8.

What regulatory lists include Cadmium?

Cadmium appears on 22 regulatory/inventory lists including OEHHA Proposition 65 (3/2019), detected; Europe; Personal care - make-up and related - eye liner, Arts and crafts/Office supplies - body paint; detected; Europe, and 19 more. Source: EPA CPDat.

Is Cadmium a carcinogen according to IARC?

Cadmium is classified by IARC as Group 1 — carcinogenic to humans (evaluated 2009). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Cadmium a Substance of Very High Concern (SVHC)?

Yes, Cadmium is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Carcinogenic (Article 57a); Specific target organ toxicity after repeated exposure (Article 57(f) - human health). Source: ECHA SVHC Candidate List.

Where does the safety data for Cadmium come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ECHA SVHC Candidate List, ILO/WHO ICSC, EPA Toxics Release Inventory, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Cadmium used outside industrial chemicals?

Cadmium also appears in food safety, cannabis databases.