What is the NOAEL for L-Isoleucine?
L-Isoleucine has 6 NOAEL studies in the database. The lowest reported value is 52.89 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Isoleucine
Also known as: Pentanoic acid, 2-amino-3-methyl-, (2S,3S)-, Isoleucine, NSC 46708, Acetic acid, amino-sec-butyl-, Acetic acid, amino(1-methylpropyl)-, (R*,R*)- (+15 more)
CAS 73-32-5
L-Isoleucine (CAS 73-32-5) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Isoleucine
CAS Number
73-32-5
DTXSID
DTXSID1047441
Molecular Formula
C6H13NO2
InChI Key
AGPKZVBTJJNPAG-WHFBIAKZSA-N
Monoisotopic Mass
131.094629
Synonyms
Pentanoic acid, 2-amino-3-methyl-, (2S,3S)-IsoleucineNSC 46708Acetic acid, amino-sec-butyl-Acetic acid, amino(1-methylpropyl)-, (R*,R*)-(S-(R*,R*))-2-Amino-3-methylpentanoic acid2-Amino-3-methylpentanoic acid, (S-(R*,R*))-EINECS 200-798-2Norvaline, 3-methyl-Pentanoic acid, 2-amino-3-methyl-Pentanoic acid, 2-amino-3-methyl-, (S-(R*,R))-Valeric acid, 2-amino-3-methyl-
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Flavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =52.89 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 04Y7590D77 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 04Y7590D77 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 04Y7590D77 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 04Y7590D77 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | L-isoleucine | 200-798-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
amino_acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ISOLEUCINE
ChEMBL Phase
2
Adverse Events
3
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Isoleucine?
L-Isoleucine appears on 3 regulatory/inventory lists including pharmaceutical, active_ingredient; Australia, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is L-Isoleucine used in cosmetics?
Yes, L-Isoleucine is also indexed as a cosmetic ingredient under the name L-Isoleucine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Isoleucine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Isoleucine used outside industrial chemicals?
L-Isoleucine also appears in cosmetics, pharmaceutical, cannabis databases.