What is the NOAEL for Delta-Dodecalactone?
Delta-Dodecalactone has 11 NOAEL studies in the database. The lowest reported value is 16.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Delta-Dodecalactone
Also known as: delta-Dodecalactone (5-Dodecanolide), 5-Dodecanolide, 2H-Pyran-2-one, 6-heptyltetrahydro-, 5-Dodecalactone, Dodecanoic acid, 5-hydroxy-, delta-lactone (+7 more)
CAS 713-95-1
Delta-Dodecalactone (CAS 713-95-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Delta-Dodecalactone
CAS Number
713-95-1
DTXSID
DTXSID9047596
Molecular Formula
C12H22O2
InChI Key
QRPLZGZHJABGRS-UHFFFAOYSA-N
Monoisotopic Mass
198.16198
Synonyms
delta-Dodecalactone (5-Dodecanolide)5-Dodecanolide2H-Pyran-2-one, 6-heptyltetrahydro-5-DodecalactoneDodecanoic acid, 5-hydroxy-, delta-lactoneDodecanolide-1,5EINECS 211-932-4FEMA No. 2401delta-Heptyl-delta-valerolactonen-Heptyl-delta-valerolactone5-Hydroxydodecanoic acid lactoneUNII-33DIC582TL
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
53 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =16.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 33DIC582TL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33DIC582TL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33DIC582TL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 33DIC582TL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 250 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dodecan-5-olide | 211-932-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL4636895
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Delta-Dodecalactone?
Delta-Dodecalactone appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Delta-Dodecalactone used in cosmetics?
Yes, Delta-Dodecalactone is also indexed as a cosmetic ingredient under the name Delta-Dodecalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Delta-Dodecalactone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Delta-Dodecalactone used outside industrial chemicals?
Delta-Dodecalactone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.