What is the NOAEL for 6-Hexyltetrahydro-2H-pyran-2-one?
6-Hexyltetrahydro-2H-pyran-2-one has 10 NOAEL studies in the database. The lowest reported value is ERL32M2M38 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
6-Hexyltetrahydro-2H-pyran-2-one
Also known as: 2H-Pyran-2-one, 6-hexyltetrahydro-, delta-Undecalactone, 5-17-09-00097, BRN 0122724, EINECS 211-915-1 (+8 more)
CAS 710-04-3
6-Hexyltetrahydro-2H-pyran-2-one (CAS 710-04-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
6-Hexyltetrahydro-2H-pyran-2-one
CAS Number
710-04-3
DTXSID
DTXSID9047099
Molecular Formula
C11H20O2
InChI Key
YZRXRLLRSPQHDK-UHFFFAOYSA-N
Monoisotopic Mass
184.14633
Synonyms
2H-Pyran-2-one, 6-hexyltetrahydro-delta-Undecalactone5-17-09-00097BRN 0122724EINECS 211-915-1FEMA No. 32945-Hexyl-5-hydroxypentanoic acid lactonedelta-Hexylvalerolactone5-Hydroxyundecanoic acid lactoneUndecanoic acid, 5-hydroxy-, delta-lactoneUndecanolide-1,55-Undecanolide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ERL32M2M38 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ERL32M2M38 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ERL32M2M38 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ERL32M2M38 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1350 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 6-hexyltetrahydro-2H-pyran-2-one | 211-915-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL372447
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 6-Hexyltetrahydro-2H-pyran-2-one?
6-Hexyltetrahydro-2H-pyran-2-one appears on 4 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe, IFRA Transparency, and 1 more. Source: EPA CPDat.
Is 6-Hexyltetrahydro-2H-pyran-2-one used in cosmetics?
Yes, 6-Hexyltetrahydro-2H-pyran-2-one is also indexed as a cosmetic ingredient under the name Delta-Undecalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 6-Hexyltetrahydro-2H-pyran-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 6-Hexyltetrahydro-2H-pyran-2-one used outside industrial chemicals?
6-Hexyltetrahydro-2H-pyran-2-one also appears in cosmetics, pharmaceutical, cannabis databases.