Danger GHS02GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

1-Butanol

Also known as: n-Butyl alcohol, n-Butanol, Butyric alcohol, Butyric or normal primary butyl alcohol, EINECS 200-751-6 (+15 more)

CAS 71-36-3

1-Butanol (CAS 71-36-3) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H302; H335; H336; H315; H318. Key regulatory status: REACH registered, 58 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for N-BUTYL ALCOHOL →

Cross-Vertical Regulatory Divergence

1-Butanol is classified GHS Danger (H226, H302, H335, H336, H315, H318) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

1-Butanol

CAS Number

71-36-3

DTXSID

DTXSID1021740

Molecular Formula

C4H10O

InChI Key

LRHPLDYGYMQRHN-UHFFFAOYSA-N

Monoisotopic Mass

74.073165

Synonyms

n-Butyl alcoholn-ButanolButyric alcoholButyric or normal primary butyl alcoholEINECS 200-751-6FEMA No. 2178FEMA Number 2178Normal primary butyl alcoholPropylmethanolRCRA waste number U031Alcool butyliqueButanolen

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; Acute Tox. 4 *; STOT SE 3; STOT SE 3; Skin Irrit. 2; Eye Dam. 1	H226; H302; H335; H336; H315; H318	GHS02; GHS07; GHS05	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Flammable liquid and vapour Harmful if swallowed Causes skin irritation Causes serious eye damage May cause respiratory irritation May cause drowsiness or dizziness May be harmful if swallowed and enters airways
Short-term Effects	The substance is corrosive to the eyes. The substance is irritating to the skin. Exposure far above the OEL could cause lowering of consciousness. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 4 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	100 ppm (300 mg/m³)	100	300	N
NIOSH	CEILING	50 ppm (150 mg/m³)	50	150	Y
CAL/OSHA	CEILING	50 ppm (150 mg/m³)	50	150	Y
NIOSH	IDLH	1400 ppm	1400	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 30 records

SolventFragranceFlavouring and nutrientPlasticizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 58 records

List	Keyword	Source
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected	Danish Environmental Protection Agency	Danish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
consumer_product; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Vehicle - car interior	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; emissions; Europe; nondetect; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
detected; drinking_water; MN Chemical Screening	EPA	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA	State of Minnesota
detected; drinking_water; MN Chemical Screening	EPA	State of Minnesota
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Europe	European Commission	Fl@vis
fracking; water	NY Department of Conservation	CPCat
Arts and crafts/Office supplies - general arts and crafts supplies; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
detected; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 68 studies

Value	Unit	Endpoint	Route	Species	Source
1066	ug/mL	CD54, EC200	Dermal	-	NTP_ICE_skin_sensitization
>200	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
>518.861	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
921	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
>1000	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
1642.8	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
=310	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
-0.4	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
0.7	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
0.9	%	Depletion Cys	Dermal	-	NTP_ICE_skin_sensitization
-1.3	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
0.1	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
1.2	%	Depletion Lys	Dermal	-	NTP_ICE_skin_sensitization
-	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
0.4	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
0.5	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
0.6	%	Depletion Lys + Cys	Dermal	-	NTP_ICE_skin_sensitization
1	-	Developmental toxicity	oral (drinking water)	Crj:CD(SD) rats	UnifiedCodex:CIR:beta.noael_studies
60.8	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
>2000	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
>20	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
8PJ61P6TS3	UNII	FDA UNII substance identifier	-	-	openFDA substances
8PJ61P6TS3	UNII	FDA UNII substance identifier	-	-	openFDA substances
8PJ61P6TS3	UNII	FDA UNII substance identifier	-	-	openFDA substances
8PJ61P6TS3	UNII	FDA UNII substance identifier	-	-	openFDA substances
1	unitless	GHS Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
2	unitless	GHS Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
>2400	uM	IC50	Dermal	-	NTP_ICE_skin_sensitization
1.146	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
1.15	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
1.617	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
0.89	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
24	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>24.2378	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=790	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=2292	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=4360	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=42442.8	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=500	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_IRIS
=1	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=5	%	LOEL	oral	Rat	ToxValDB_ECOTOX
=500	mg/kg bw/day	LOEL	oral	Rat	ToxValDB_ECOTOX
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
=0.1	mg/m3	NOAEL	-	-	INCHEM_WHO_ehc_ehc_ehc65
=1	%	NOAEL	-	rat	CIR_vision_codex
=1	-	NOAEL	oral (drinking water)	Crj:CD(SD) rats	CIR_vision_codex
=1	%	NOAEL	-	rat	CIR_vision_codex
=1	-	NOAEL	oral (drinking water)	Crj:CD(SD) rats	CIR_vision_codex
=1	%	NOAEL	-	rat	CIR_vision_codex
=1	-	NOAEL	oral (drinking water)	Crj:CD(SD) rats	CIR_vision_codex

Showing 50 of 68 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Butan-1-ol	200-751-6	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
n-Butyl alcohol (1-Butanol)	-	-

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BUTYL ALCOHOL

ChEMBL Phase

-1

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Butanol?

1-Butanol (CAS 71-36-3) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 *; STOT SE 3; STOT SE 3; Skin Irrit. 2; Eye Dam. 1 with signal word Danger. Hazard statements: H226; H302; H335; H336; H315; H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Butanol?

1-Butanol has 68 NOAEL studies in the database. The lowest reported value is -1.3 % via Dermal. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 1-Butanol?

1-Butanol appears on 29 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected, and 26 more. Source: EPA CPDat.

What are the occupational exposure limits for 1-Butanol?

Occupational exposure limits for 1-Butanol are set by OSHA, NIOSH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1-Butanol used in cosmetics?

Yes, 1-Butanol is also indexed as a cosmetic ingredient under the name N-BUTYL ALCOHOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Butanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Butanol have different safety status in cosmetics vs industrial chemicals?

1-Butanol is classified GHS Danger (H226, H302, H335, H336, H315, H318) in the chemicals database but is allowed in EU cosmetics.

Is 1-Butanol used outside industrial chemicals?

1-Butanol also appears in cosmetics, pharmaceutical, cannabis databases.