What is the NOAEL for 6-Pentyltetrahydro-2H-pyran-2-one?
6-Pentyltetrahydro-2H-pyran-2-one has 12 NOAEL studies in the database. The lowest reported value is 49.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
6-Pentyltetrahydro-2H-pyran-2-one
Also known as: 2H-Pyran-2-one, tetrahydro-6-pentyl-, 5-Decanolide, 5-Pentyl-5-pentanolide, Tetrahydro-6-pentyl-2H-pyran-2-one, δ-Decalactone (+15 more)
CAS 705-86-2
6-Pentyltetrahydro-2H-pyran-2-one (CAS 705-86-2) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
6-Pentyltetrahydro-2H-pyran-2-one
CAS Number
705-86-2
DTXSID
DTXSID0044496
Molecular Formula
C10H18O2
InChI Key
GHBSPIPJMLAMEP-UHFFFAOYSA-N
Monoisotopic Mass
170.13068
Synonyms
2H-Pyran-2-one, tetrahydro-6-pentyl-5-Decanolide5-Pentyl-5-pentanolideTetrahydro-6-pentyl-2H-pyran-2-oneδ-Decalactoneδ-Amylvalerolactoneδ-Pentyl-δ-valerolactone(+/-)-5-Hydroxydecanoic acid lactone(+/-)-δ-Decalactone(RS)-δ-Decalactoneδ-Amyl-δ-valerolactoneDecanoic acid, 5-hydroxy-, δ-lactone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DeodorizerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =49.3 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| CNA0S5T234 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CNA0S5T234 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CNA0S5T234 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CNA0S5T234 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 250 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Decan-5-olide | 211-889-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182189
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 6-Pentyltetrahydro-2H-pyran-2-one?
6-Pentyltetrahydro-2H-pyran-2-one appears on 5 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is 6-Pentyltetrahydro-2H-pyran-2-one used in cosmetics?
Yes, 6-Pentyltetrahydro-2H-pyran-2-one is also indexed as a cosmetic ingredient under the name Delta-Decalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 6-Pentyltetrahydro-2H-pyran-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 6-Pentyltetrahydro-2H-pyran-2-one used outside industrial chemicals?
6-Pentyltetrahydro-2H-pyran-2-one also appears in cosmetics, pharmaceutical, food safety, cannabis databases.