Danger GHS08GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Sodium N-(hydroxymethyl)glycinate

Also known as: Glycine, N-(hydroxymethyl)-, sodium salt (1:1), Sodium (hydroxymethyl)glycinate, N-(Hydroxymethyl)glycine, monosodium salt, Glycine, N-(hydroxymethyl)-, monosodium salt, EINECS 274-357-8 (+4 more)

CAS 70161-44-3

Sodium N-(hydroxymethyl)glycinate (CAS 70161-44-3) is a chemical substance with GHS signal word Danger; key hazard signal: H350; H341; H332; H302; H335; H315; H319; H317. Key regulatory status: REACH registered, 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Sodium Hydroxymethylglycinate →

SOURCE noael studies public
NOAEL studies
22
SOURCE chemical inventory jurisdictions
Regulatory lists
17
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields
Name
Sodium N-(hydroxymethyl)glycinate
CAS Number
70161-44-3
DTXSID
DTXSID5035799
Molecular Formula
C3H7NO3.Na
InChI Key
CITBNDNUEPMTFC-UHFFFAOYSA-M
Synonyms
Glycine, N-(hydroxymethyl)-, sodium salt (1:1)Sodium (hydroxymethyl)glycinateN-(Hydroxymethyl)glycine, monosodium saltGlycine, N-(hydroxymethyl)-, monosodium saltEINECS 274-357-8Sodium hydroxymethylamino acetateHydroxymethylglycine, sodium saltsodium hydroxymethylglycinateUNII-DIG6BWZ9XT

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Carc. 1B; Muta. 2; Acute Tox. 4; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1H350; H341; H332; H302; H335; H315; H319; H317GHS08; GHS07Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 35 records
PreservativeSoftener and conditionerBiocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 17 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
Europe; Personal careEuropean CommissionCosIng
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
Europe; Personal care - body hygiene - hand soapDanish Environmental Protection AgencyDanish EPA
Europe; Personal careDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 22 of 22 studies
ValueUnitEndpointRouteSpeciesSource
=11.3mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
DIG6BWZ9XTUNIIFDA UNII substance identifier--openFDA substances
DIG6BWZ9XTUNIIFDA UNII substance identifier--openFDA substances
DIG6BWZ9XTUNIIFDA UNII substance identifier--openFDA substances
DIG6BWZ9XTUNIIFDA UNII substance identifier--openFDA substances
>2.3mg/LLC50Inhalation-NTP_ICE_acute_inhalation
6mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=40mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=40mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=150mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=150mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
>160mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=450mg/kg bw/dayLOAELoralRatToxValDB_ToxRefDB
=450mg/kg bw/dayLOAELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=640mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=640mg/kg bw/dayLOAELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
>-mg/kg bw/dayNELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
>=160mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=160mg/kg bw/dayNOAELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=300mg/kg bw/dayNOAELoralrat (sprague dawley; Sprague Dawley)ToxRefDB_ToxRefDB_v3_pod.csv
=450mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=300mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID

Showing 22 of 22 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredSodium N-(hydroxymethyl)glycinate274-357-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.5%
Category
preservative
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Sodium N-(hydroxymethyl)glycinate?

Sodium N-(hydroxymethyl)glycinate (CAS 70161-44-3) is classified under EU CLP Annex VI as Carc. 1B; Muta. 2; Acute Tox. 4; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1 with signal word Danger. Hazard statements: H350; H341; H332; H302; H335; H315; H319; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Sodium N-(hydroxymethyl)glycinate?

Sodium N-(hydroxymethyl)glycinate has 22 NOAEL studies in the database. The lowest reported value is 11.3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Sodium N-(hydroxymethyl)glycinate?

Sodium N-(hydroxymethyl)glycinate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Europe; Personal care, Canada; Personal care; Substances in PCP - Canada (4/2014), and 3 more. Source: EPA CPDat.

Is Sodium N-(hydroxymethyl)glycinate used in cosmetics?

Yes, Sodium N-(hydroxymethyl)glycinate is also indexed as a cosmetic ingredient under the name Sodium Hydroxymethylglycinate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Sodium N-(hydroxymethyl)glycinate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Sodium N-(hydroxymethyl)glycinate have different safety status in cosmetics vs industrial chemicals?

Sodium N-(hydroxymethyl)glycinate is classified GHS Danger (H350, H341, H332, H302, H335, H315, H319, H317) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

Is Sodium N-(hydroxymethyl)glycinate used outside industrial chemicals?

Sodium N-(hydroxymethyl)glycinate also appears in cosmetics databases.