Danger GHS06GHS09 NOAEL Data IARC Group 3 Cosmetic Ingredient

Hexachlorophene

Also known as: 2,2'-Methylene bis(3,4,6-trichlorophenol), B & b Flea Kontroller for Dogs Only, Blockade Anti Bacterial Finish, Brevity Blue Liquid Bacteriostatic Scouring Cream, Brevity Blue Liquid Sanitizing Scouring Cream (+15 more)

CAS 70-30-4

Hexachlorophene (CAS 70-30-4) is a chemical substance with GHS signal word Danger; key hazard signal: H311; H301; H400; H410. Key regulatory status: 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, IARC, EPA TRI.

View cosmetic safety profile for Hexachlorophene →

SOURCE noael studies public
NOAEL studies
51
SOURCE chemical inventory jurisdictions
Regulatory lists
9
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Hexachlorophene
CAS Number
70-30-4
DTXSID
DTXSID6020690
Molecular Formula
C13H6Cl6O2
InChI Key
ACGUYXCXAPNIKK-UHFFFAOYSA-N
Monoisotopic Mass
403.849896
Synonyms
2,2'-Methylene bis(3,4,6-trichlorophenol)B & b Flea Kontroller for Dogs OnlyBlockade Anti Bacterial FinishBrevity Blue Liquid Bacteriostatic Scouring CreamBrevity Blue Liquid Sanitizing Scouring CreamBRN 2064407Caswell No. 566Compound G-11EINECS 200-733-8G-ElevenEnditch Pet ShampooEn-Viron D Concentrated Phenolic Disinfectant

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable198720, Sup 7

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chronic 1H311; H301; H400; H410GHS06; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Preservative

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records
ListKeywordSource
banned; Europe; Personal careEuropean CommissionCosIng
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 51 studies
ValueUnitEndpointRouteSpeciesSource
-uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
2.375%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
4%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
11%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
31.25%Concentration, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
0.5%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
3.333%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
10%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
25%Concentration, one positive responseDermalHumanNTP_ICE_skin_sensitization
IWW5FV6NK2UNIIFDA UNII substance identifier--openFDA substances
IWW5FV6NK2UNIIFDA UNII substance identifier--openFDA substances
IWW5FV6NK2UNIIFDA UNII substance identifier--openFDA substances
IWW5FV6NK2UNIIFDA UNII substance identifier--openFDA substances
8.62e-9fractionFu-HumanNTP_ICE_adme_parameters
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP_ICE_cancer
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
1.053%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
4.545%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
12.5%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
348.8ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
3488ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
6207ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
13950ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
15520ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
1657ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
2483ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
6828ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
19400ug/cm2Induction dose per skin area, 5% incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
2069ug/cm2Induction dose per skin area, one positive responseDermalHumanNTP_ICE_skin_sensitization
0.34mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=6mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=9mg/kg bwLD50oralRatNTP_ICE_acute_oral
=25mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=56mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
=60mg/kg bwLD50oralRat (Male/Female)NTP_ICE_acute_oral
=63mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
=66mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=104mg/kg bwLD50oralRatNTP_ICE_acute_oral
=120mg/kg bwLD50oralRatNTP_ICE_acute_oral
=146mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=161mg/kg bwLD50oralRatNTP_ICE_acute_oral
=186mg/kg bwLD50oralRatNTP_ICE_acute_oral
=0.75mg/kg bw/dayLELoralDogToxValDB_IRIS
=0.75mg/kg/dayLELoral-EPA_IRIS_iris_rfd_systems.csv
1unitlessRelative reliability scoreDermalHumanNTP_ICE_skin_sensitization
3unitlessRelative reliability scoreDermalHumanNTP_ICE_skin_sensitization
=0.0003mg/kg bw/dayRfDoralHumanToxValDB_IRIS
=0.0003mg/kg/dayRfDoral-EPA_IRIS_iris_rfd_systems.csv
=0.003mg/kg bw/dayRfDoralHumanToxValDB_RSL

Showing 50 of 51 studies

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Hexachlorophene--

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL HEXACHLOROPHENE
ChEMBL Phase
4
Adverse Events
22
Bioactivity
45
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Hexachlorophene?

Hexachlorophene (CAS 70-30-4) is classified under EU CLP Annex VI as Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H311; H301; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Hexachlorophene?

Hexachlorophene has 51 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Hexachlorophene?

Hexachlorophene appears on 6 regulatory/inventory lists including banned; Europe; Personal care, Europe; nondetect; Other direct contact consumer goods, active_ingredient; Europe; Pesticides, and 3 more. Source: EPA CPDat.

Is Hexachlorophene a carcinogen according to IARC?

Hexachlorophene is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Hexachlorophene used in cosmetics?

Yes, Hexachlorophene is also indexed as a cosmetic ingredient under the name Hexachlorophene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hexachlorophene come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, IARC Monographs, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Hexachlorophene have different safety status in cosmetics vs industrial chemicals?

Hexachlorophene is classified GHS Danger (H311, H301, H400, H410) in the chemicals database but is restricted in EU cosmetics.

Is Hexachlorophene used outside industrial chemicals?

Hexachlorophene also appears in cosmetics, pharmaceutical databases.