What is the NOAEL for Bixin?
Bixin has 16 NOAEL studies in the database. The lowest reported value is 0.3 mg/kg bw/day in Consumers. Source: EFSA.
NOAEL Data
Cosmetic Ingredient
Bixin
Also known as: cis-Bixin, 6,6'-Diapo-psi,psi-carotenedioic acid, 6-methyl ester, 9-cis-, 2,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid,4,8,13,17-tetramethyl-,monomethyl ester, (2E,4Z,6E,8E,10E,12E,14E,16E,18E)-, EINECS 230-248-7, UNII-9L7T4VB66G (+3 more)
CAS 6983-79-5
Bixin (CAS 6983-79-5) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS.
Cross-Vertical Regulatory Divergence
Bixin is classified GHS Danger (H302, H311, H315, H319, H331, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
16
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Bixin
CAS Number
6983-79-5
DTXSID
DTXSID1024629
Molecular Formula
C25H30O4
InChI Key
RAFGELQLHMBRHD-SLEZCNMESA-N
Monoisotopic Mass
394.214409
Synonyms
cis-Bixin6,6'-Diapo-psi,psi-carotenedioic acid, 6-methyl ester, 9-cis-2,4,6,8,10,12,14,16,18-Eicosanonaenedioic acid,4,8,13,17-tetramethyl-,monomethyl ester, (2E,4Z,6E,8E,10E,12E,14E,16E,18E)-EINECS 230-248-7UNII-9L7T4VB66G6'-methyl hydrogen 9'-Z-6,6'-diapocarotene-6,6'-dioate6'-methyl hydrogen 9'-cis-6,6'-diapocarotene-6,6'-dioateMethyl (9-cis)-hydrogen-6,6'-diapo-psi,psi-carotenedioate
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.3 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =0.3 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =6 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =6 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =6 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =6 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =6 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| =6 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| 9L7T4VB66G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L7T4VB66G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L7T4VB66G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9L7T4VB66G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =191 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =191 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =1206 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
| =1206 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA |
Showing 16 of 16 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Colorants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
BIXIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
Is Bixin used in cosmetics?
Yes, Bixin is also indexed as a cosmetic ingredient under the name Bixin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Bixin come from?
Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Bixin have different safety status in cosmetics vs industrial chemicals?
Bixin is classified GHS Danger (H302, H311, H315, H319, H331, H335) in the chemicals database but is allowed in EU cosmetics.
Is Bixin used outside industrial chemicals?
Bixin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.