What is the NOAEL for 1,2-Hexanediol?
1,2-Hexanediol has 8 NOAEL studies in the database. The lowest reported value is 123 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,2-Hexanediol
CAS 6920-22-5
1,2-Hexanediol (CAS 6920-22-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
6 fields
Name
1,2-Hexanediol
CAS Number
6920-22-5
DTXSID
DTXSID40863959
Molecular Formula
C6H14O2
InChI Key
FHKSXSQHXQEMOK-UHFFFAOYSA-N
Monoisotopic Mass
118.09938
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
9 records
SolventSoftener and conditionerFragranceHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | - | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =123 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| TR046Y3K1G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TR046Y3K1G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TR046Y3K1G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TR046Y3K1G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1000 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =700 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | DL-hexane-1,2-diol | 230-029-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
solvent
Frequently Asked Questions
What regulatory lists include 1,2-Hexanediol?
1,2-Hexanediol appears on 4 regulatory/inventory lists including air; Cons electronics mech appliances and machinery; detected; emissions; Europe, IFRA Transparency, SCIL (9/2019), and 1 more. Source: EPA CPDat.
Is 1,2-Hexanediol used in cosmetics?
Yes, 1,2-Hexanediol is also indexed as a cosmetic ingredient under the name 1,2-Hexanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,2-Hexanediol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,2-Hexanediol used outside industrial chemicals?
1,2-Hexanediol also appears in cosmetics databases.