What is the NOAEL for Tea tree oil?
Tea tree oil has 100 NOAEL studies in the database. The lowest reported value is 0.117 mg/kg bw/day via oral in rat. Source: SCCS_vision_codex.
NOAEL Data
Cosmetic Ingredient
Tea tree oil
Also known as: Essential oils, Melaleuca alternifolia, Oils, essential, Melaleuca alternifolia, Oils, tea-tree, Essential oils, tea tree, Melaleuca aetheroleum (+14 more)
CAS 68647-73-4
Tea tree oil (CAS 68647-73-4) is a chemical substance. Key regulatory status: 17 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS.
View cosmetic safety profile for Melaleuca Alternifolia (Tea Tree) Leaf Oil →
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
17
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Tea tree oil
CAS Number
68647-73-4
DTXSID
DTXSID60100611
Synonyms
Essential oils, Melaleuca alternifoliaOils, essential, Melaleuca alternifoliaOils, tea-treeEssential oils, tea treeMelaleuca aetheroleumMelaleuca alternifolia leaf oilMelaleuca alternifolia oilsMelaleuca oilMulticropOil of Melaleuca alternifolia (cheel)Oil, MelaleucaOils, tea tree
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
AntioxidantFragranceBiocideFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
17 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Personal care - body oil | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 3 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 4.5 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 5 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 6 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 15 | % | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 30 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 40 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 40 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 40 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 40 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 40 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | mg/kg bw/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 60 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 75 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 75 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 75 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 75 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =100 | % | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 250 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 300 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 300 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 400 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 500 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 500 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 510 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| VIF565UC2G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VIF565UC2G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VIF565UC2G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VIF565UC2G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 675 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =0.117 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =0.117 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =0.117 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =0.117 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =3 | - | NOAEL | - | - | SCCS_vision_codex |
| =3 | - | NOAEL | - | - | SCCS_vision_codex |
| =3 | - | NOAEL | - | - | SCCS_vision_codex |
| =3 | - | NOAEL | - | - | SCCS_vision_codex |
| =4.5 | % | NOAEL | - | - | SCCS_vision_codex |
| =4.5 | % | NOAEL | - | - | SCCS_vision_codex |
| =4.5 | % | NOAEL | - | - | SCCS_vision_codex |
| =4.5 | % | NOAEL | - | - | SCCS_vision_codex |
| =5 | % | NOAEL | - | rat | SCCS_vision_codex |
| =5 | % | NOAEL | - | rat | SCCS_vision_codex |
| =5 | % | NOAEL | - | rat | SCCS_vision_codex |
| =5 | % | NOAEL | - | rat | SCCS_vision_codex |
| =6 | % | NOAEL | - | - | SCCS_vision_codex |
| =6 | % | NOAEL | - | - | SCCS_vision_codex |
Showing 50 of 100 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
3 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1681/25 | 30 October 2025 | safe with restrictions | Rinse-off: up to specified concentrations; leave-on: up to specified concentrations | Possible Repr.1B classification under CLP; stability of TTO must be maintained; terpinen-4-ol type required; concerns about reproductive toxicity; no aerosolised/sprayable formats |
| SCCP/1184/08 | 16 December 2008 | safe with restrictions | 1% leave-on; 5% rinse-off (2008 assessment) | Skin sensitisation potential; oxidation products more sensitising; must be stored appropriately; updated in SCCS/1681/25 |
| SCCP/0843/04 | 7 December 2004 | safe with restrictions | 1% leave-on; 5% rinse-off (preliminary 2004 assessment) | Oxidation products are sensitisers; must be within ISO 4730 composition; updated by SCCP/1184/08 and SCCS/1681/25 |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
18
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Tea tree oil?
Tea tree oil appears on 12 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Canada; consumer_product; Substances in Products - Canada (4/2014), children; Europe; Personal care, and 9 more. Source: EPA CPDat.
Is Tea tree oil used in cosmetics?
Yes, Tea tree oil is also indexed as a cosmetic ingredient under the name Melaleuca Alternifolia (Tea Tree) Leaf Oil. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tea tree oil come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Tea tree oil used outside industrial chemicals?
Tea tree oil also appears in cosmetics, pharmaceutical, cannabis databases.