What is the NOAEL for Vitamin B12?
Vitamin B12 has 7 NOAEL studies in the database. The lowest reported value is P6YC3EG204 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Vitamin B12
Also known as: Cyanocobalamin, 1H-Benzimidazole, 5,6-dimethyl-1-(3-O-phosphono-α-D-ribofuranosyl)-, monoester with cobinamide cyanide, inner salt, 5,6-Dimethylbenzimidazolyl cyanocobamide, 5,6-Dimethylbenzimidazolyl-Co-cyanocobamide, Cobalamin (vitamin B12) (+15 more)
CAS 68-19-9
Vitamin B12 (CAS 68-19-9) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
10
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Vitamin B12
CAS Number
68-19-9
DTXSID
DTXSID7044346
Molecular Formula
C62H90N13O14P.CN.Co
InChI Key
FDJOLVPMNUYSCM-SYUKHSAKSA-L
Monoisotopic Mass
1356.58305
Synonyms
Cyanocobalamin1H-Benzimidazole, 5,6-dimethyl-1-(3-O-phosphono-α-D-ribofuranosyl)-, monoester with cobinamide cyanide, inner salt5,6-Dimethylbenzimidazolyl cyanocobamide5,6-Dimethylbenzimidazolyl-Co-cyanocobamideCobalamin (vitamin B12)1H-Benzimidazole, 5,6-dimethyl-1-(3-O-phosphono-alpha-D-ribofuranosyl)-, monoester with cobinamide cyanide hydroxide, inner saltBevatine-12BRN 4122889Cobamide, alpha-5,6-dimethyl-1H-benzimidazolyl-, cyanideCobinamide, cyanide hydroxide, dihydrogen phosphateCobinamide, cyanide hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazoleCobione
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
Softener and conditionerFlavouring and nutrientPharmaceuticalThickening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| P6YC3EG204 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P6YC3EG204 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P6YC3EG204 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P6YC3EG204 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.02 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 0.1 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Cyanocobalamin | 200-680-0 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
cyanocobalamin
ChEMBL Phase
Not listed
Adverse Events
12148
Bioactivity
7
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Vitamin B12?
Vitamin B12 appears on 8 regulatory/inventory lists including pharmaceutical, Europe; supplements, Europe; food_additive; supplements, and 5 more. Source: EPA CPDat.
Is Vitamin B12 used in cosmetics?
Yes, Vitamin B12 is also indexed as a cosmetic ingredient under the name CYANOCOBALAMIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Vitamin B12 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Vitamin B12 used outside industrial chemicals?
Vitamin B12 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.