Danger GHS06GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

Thioglycolic acid

Also known as: Acetic acid, mercapto-, 4-03-00-00600, BRN 0506166, EINECS 200-677-4, Glycolic acid, thio- (+9 more)

CAS 68-11-1

Thioglycolic acid (CAS 68-11-1) is a chemical substance with GHS signal word Danger; key hazard signal: H331; H311; H301; H314. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, SCCS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Thioglycolic Acid →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields
Name
Thioglycolic acid
CAS Number
68-11-1
DTXSID
DTXSID8026141
Molecular Formula
C2H4O2S
InChI Key
CWERGRDVMFNCDR-UHFFFAOYSA-N
Monoisotopic Mass
91.993201
Synonyms
Acetic acid, mercapto-4-03-00-00600BRN 0506166EINECS 200-677-4Glycolic acid, thio-ThioglycolateAcide thioglycoliqueKyselina merkaptooctovaKyselina thioglykolovaUNII-7857H94KHMMercaptoessigsaeureMerkaptoessigsaeure

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1BH331; H311; H301; H314GHS06; GHS05Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Exposure could cause death. The effects may be delayed. Medical observation is indicated. See Notes.
Routes of ExposureThe substance can be absorbed into the body by inhalation, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 3 records
AgencyMetricValueppmmg/m3Skin
NIOSHTWA1 ppm (4 mg/m³)14Y
ACGIHTWA1 ppm [2017]1-Y
CAL/OSHATWA1 ppm (3.8 mg/m³)13.8Y

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 13 records
AntioxidantReducing agentDepilatoryHair waving or straightening

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
frackingFracFocusFracFocus
Canada; pharmaceuticalDrugBankDrugBank
fracking; waterNY Department of ConservationCPCat
Europe; Personal care; restrictedEuropean CommissionCosIng
Personal care; Southeast AsiaAseanASEAN Cosmetics

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
=1.66mg/kg bw-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
11%-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=129mg/kg bw/d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=180mg/kg bw/d-dermalratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
11.62minBreakthrough TimeDermal-NTP_ICE_skin_irritation
35.6minBreakthrough TimeDermal-NTP_ICE_skin_irritation
37.7minBreakthrough TimeDermal-NTP_ICE_skin_irritation
=1.58mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
7857H94KHMUNIIFDA UNII substance identifier--openFDA substances
7857H94KHMUNIIFDA UNII substance identifier--openFDA substances
7857H94KHMUNIIFDA UNII substance identifier--openFDA substances
7857H94KHMUNIIFDA UNII substance identifier--openFDA substances
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
1476ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
0.21mg/LLC50Inhalation-NTP_ICE_acute_inhalation
1.094mg/LLC50Inhalation-NTP_ICE_acute_inhalation
1.388mg/LLC50Inhalation-NTP_ICE_acute_inhalation
1.981mg/LLC50Inhalation-NTP_ICE_acute_inhalation
-unitlessModel Score--NTP_ICE_endocrine
=0.044mg/kg bwNOAELdermalratSCCS_vision_codex
=0.044mg/kg bwNOAELdermalratSCCS_vision_codex
=0.044mg/kg bwNOAELdermalratSCCS_vision_codex
=0.044mg/kg bwNOAELdermalratSCCS_vision_codex
=1.66mg/kg bwNOAELdermalratSCCS_vision_codex
=1.66mg/kg bwNOAELdermalratSCCS_vision_codex
=1.66mg/kg bwNOAELdermalratSCCS_vision_codex
=1.66mg/kg bwNOAELdermalratSCCS_vision_codex
=7mg/kg bw/dNOAELoralratSCCS_vision_codex
=7mg/kg bw/dNOAELoralratSCCS_vision_codex
=7mg/kg bw/dNOAELoralratSCCS_vision_codex
=7mg/kg bw/dNOAELoralratSCCS_vision_codex
=11%NOAELdermalratSCCS_vision_codex
=11%NOAELdermalratSCCS_vision_codex
=11%NOAELdermalratSCCS_vision_codex
=11%NOAELdermalratSCCS_vision_codex
=11.25mg/kg bw/dNOAELdermalratSCCS_vision_codex
=11.25mg/kg bw/dNOAELdermalratSCCS_vision_codex
=11.25mg/kg bw/dNOAELdermalratSCCS_vision_codex
=11.25mg/kg bw/dNOAELdermalratSCCS_vision_codex
=20mg/kg bw/dNOAELoralratSCCS_vision_codex
=20mg/kg bw/dNOAELoralratSCCS_vision_codex
=20mg/kg bw/dNOAELoralratSCCS_vision_codex
=20mg/kg bw/dNOAELoralratSCCS_vision_codex
=45mg/kg bw/dNOAELoralratSCCS_vision_codex
=45mg/kg bw/dNOAELoralratSCCS_vision_codex
=45mg/kg bw/dNOAELoralratSCCS_vision_codex
=45mg/kg bw/dNOAELoralratSCCS_vision_codex
=65mg/kg bw/dayNOAELoralratSCCS_vision_codex

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredMercaptoacetic acid200-677-4ECHA overview →

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1520/1311 November 2013safe with restrictionsHair products: 11% (as TGA); Cold wave: 11% (professional); General cosmetics: 8%Skin irritation potential; thioglycolic acid is caustic; concentration limits differ for professional vs consumer use

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
5.0%
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL THIOGLYCOLIC ACID
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Thioglycolic acid?

Thioglycolic acid (CAS 68-11-1) is classified under EU CLP Annex VI as Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B with signal word Danger. Hazard statements: H331; H311; H301; H314. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Thioglycolic acid?

Thioglycolic acid has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Thioglycolic acid?

Thioglycolic acid appears on 5 regulatory/inventory lists including fracking, Canada; pharmaceutical, fracking; water, and 2 more. Source: EPA CPDat.

What are the occupational exposure limits for Thioglycolic acid?

Occupational exposure limits for Thioglycolic acid are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Thioglycolic acid used in cosmetics?

Yes, Thioglycolic acid is also indexed as a cosmetic ingredient under the name Thioglycolic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Thioglycolic acid come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Thioglycolic acid have different safety status in cosmetics vs industrial chemicals?

Thioglycolic acid is prohibited in EU cosmetics at max 5.0% but has active industrial GHS classifications (H331, H311, H301, H314).

Is Thioglycolic acid used outside industrial chemicals?

Thioglycolic acid also appears in cosmetics, pharmaceutical databases.