What is the NOAEL for Trisodium citrate?
Trisodium citrate has 10 NOAEL studies in the database. The lowest reported value is RS7A450LGA UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Trisodium citrate
Also known as: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, Sodium citrate (Na3C6H5O7), Citric acid, trisodium salt, 331iii, Citra-lock (+13 more)
CAS 68-04-2
Trisodium citrate (CAS 68-04-2) is a chemical substance. Key regulatory status: REACH registered, 20 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
20
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Trisodium citrate
CAS Number
68-04-2
DTXSID
DTXSID2026363
Molecular Formula
C6H8O7.3Na
InChI Key
HRXKRNGNAMMEHJ-UHFFFAOYSA-K
Monoisotopic Mass
260.99631
Synonyms
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium saltSodium citrate (Na3C6H5O7)Citric acid, trisodium salt331iiiCitra-lockIonalUnifine P 3UrisalSodium citrate anhydrousSodium citrate, anhydrousCitrosodnaEINECS 200-675-3
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Chelating agentpH regulating agentDeodorizerNo specific technical functionFlavouring and nutrientSurfactant (surface active agent)PharmaceuticalFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
20 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cleaning products and household care - oven - oven cleaner; Europe | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair styling and care - shampoo-dandruff | Danish Environmental Protection Agency | Danish EPA |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| fracking; water | NY Department of Conservation | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| RS7A450LGA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RS7A450LGA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RS7A450LGA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RS7A450LGA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =8000 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =16000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =4000 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| 4450 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =8000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Trisodium citrate | 200-675-3 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
pH-adjuster
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM CITRATE
ChEMBL Phase
4
Adverse Events
1517
Bioactivity
4
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E331 — ADI: NOT LIMITED ("Not specified") mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Trisodium citrate?
Trisodium citrate appears on 18 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Cleaning products and household care - oven - oven cleaner; Europe, and 15 more. Source: EPA CPDat.
Is Trisodium citrate used in cosmetics?
Yes, Trisodium citrate is also indexed as a cosmetic ingredient under the name Sodium Citrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Trisodium citrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Trisodium citrate used outside industrial chemicals?
Trisodium citrate also appears in cosmetics, pharmaceutical, food safety databases.