What is the NOAEL for (-)-Ambroxide?
(-)-Ambroxide has 8 NOAEL studies in the database. The lowest reported value is 2.254 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
(-)-Ambroxide
Also known as: Dodecahydro-3a,6,6,9a-tetramethylnaphtho(2,1-b)furan, (3aR-(3aalpha,5abeta,9aalpha,9bbeta))-, EINECS 229-861-2, Naphtho(2,1-b)furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR-(3aalpha,5abeta,9aalpha,9bbeta))-, 8alpha,12-Oxido-13,14,15,16-tetranorlabdane, Ambroxide (+2 more)
CAS 6790-58-5
(-)-Ambroxide (CAS 6790-58-5) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Dodecahydro-Tetramethylnaphthofuran (Ambroxan) →
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
(-)-Ambroxide
CAS Number
6790-58-5
DTXSID
DTXSID0047113
Molecular Formula
C16H28O
InChI Key
YPZUZOLGGMJZJO-LQKXBSAESA-N
Monoisotopic Mass
236.214016
Synonyms
Dodecahydro-3a,6,6,9a-tetramethylnaphtho(2,1-b)furan, (3aR-(3aalpha,5abeta,9aalpha,9bbeta))-EINECS 229-861-2Naphtho(2,1-b)furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR-(3aalpha,5abeta,9aalpha,9bbeta))-8alpha,12-Oxido-13,14,15,16-tetranorlabdaneAmbroxideambroxambroxan
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
31 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.254 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =4.93 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| TD34B3O8M9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TD34B3O8M9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TD34B3O8M9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TD34B3O8M9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.01541 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [3aR-(3aα,5aβ,9aα,9bβ)]-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan | 229-861-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL496447
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include (-)-Ambroxide?
(-)-Ambroxide appears on 2 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), IFRA Transparency. Source: EPA CPDat.
Is (-)-Ambroxide used in cosmetics?
Yes, (-)-Ambroxide is also indexed as a cosmetic ingredient under the name Dodecahydro-Tetramethylnaphthofuran (Ambroxan). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for (-)-Ambroxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is (-)-Ambroxide used outside industrial chemicals?
(-)-Ambroxide also appears in cosmetics, pharmaceutical databases.