What is the GHS hazard classification for Acetone?
Acetone (CAS 67-64-1) is classified under EU CLP Annex VI as Flam. Liq. 2; STOT SE 3; Eye Irrit. 2 with signal word Danger. Hazard statements: H225; H336; H319. Source: EU CLP Annex VI (ECHA).
Danger
GHS02GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acetone
Also known as: Caswell No. 004, Chevron acetone, Dimethylketal, EINECS 200-662-2, EPA Pesticide Chemical Code 004101 (+13 more)
CAS 67-64-1
Acetone (CAS 67-64-1) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H336; H319. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Acetone is classified GHS Danger (H225, H336, H319) in the chemicals database but is allowed in EU cosmetics.
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Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
91
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
24 fields
Name
Acetone
CAS Number
67-64-1
DTXSID
DTXSID8021482
Molecular Formula
C3H6O
InChI Key
CSCPPACGZOOCGX-UHFFFAOYSA-N
Monoisotopic Mass
58.041865
Synonyms
Caswell No. 004Chevron acetoneDimethylketalEINECS 200-662-2EPA Pesticide Chemical Code 004101FEMA No. 3326Ketone, dimethylKetone propanePyroacetic acidRCRA waste number U002UNII-1364PS73AFAceton
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; STOT SE 3; Eye Irrit. 2 | H225; H336; H319 | GHS02; GHS07 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Causes eye irritation May cause respiratory irritation |
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. Exposure at high levels could cause lowering of consciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
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OSHA / NIOSH / ACGIH occupational exposure limits
6 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 1000 ppm (2400 mg/m³) | 1000 | 2400 | N |
| NIOSH | TWA | 250 ppm (590 mg/m³) | 250 | 590 | N |
| CAL/OSHA | TWA | 500 ppm (1200 mg/m³) | 500 | 1200 | N |
| CAL/OSHA | STEL | 750 ppm (1780 mg/m³) | 750 | 1780 | N |
| CAL/OSHA | CEILING | 3000 ppm | 3000 | - | N |
| NIOSH | IDLH | 2500 ppm (10% LEL) | 2500 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
SolventFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| air; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| air; Construction and building materials; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| air; consumer_product; detected; emissions | Elsevier | CPCat |
| consumer_product; detected | Elsevier | CPCat |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 50 of 91 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.9 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.9 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =57 | mg/kg bw/day | BMDL (1SD) | oral | Rat | ToxValDB_ATSDR_MRLs |
| =1210 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 65.8 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 65.8 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 65.8 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 65.8 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1364PS73AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.21 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.21 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.21 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 0.21 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 50.0697 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 50.1 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 75.9579 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 76 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 132.2308 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =5800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =8450 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =9800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =61762.3 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =50 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_DOE_Wildlife_Benchmarks |
| =539.232 | mg/m3 | LOAEL | inhalation | Human | ToxValDB_TX_TCEQ |
| =562.987 | mg/m3 | LOAEL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =562.987 | mg/m3 | LOAEL | inhalation | Human (M/F) | ATSDR_toxval_ATSDR_MRLs.xlsx |
| =890.802 | mg/m3 | LOAEL | inhalation | Human | ToxValDB_TX_TCEQ |
| =1700 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_IRIS |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| =0.6 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =0.6 | mg/kg bw/day | MRL | oral | Human | ToxValDB_ATSDR_MRLs |
| =19.0038 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =19.0038 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
| =2375.47 | mg/m3 | NEL | inhalation | Human | ToxValDB_NIOSH_IDLH |
| =4988.49 | mg/m3 | NEL | inhalation | Human | ToxValDB_NIOSH_IDLH |
| =10 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_DOE_Wildlife_Benchmarks |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | INCHEM_WHO_ehc_ehc_ehc207 |
| =500 | mg/kg bw | NOAEL | oral | Rat | INCHEM_WHO_ehc_ehc_ehc207 |
| =900 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =900 | mg/kg bw/day | NOAEL | oral: drinking water | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =900 | mg/kg/day | NOAEL | oral | - | EPA_IRIS_iris_rfd_systems.csv |
Showing 50 of 91 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Acetone | 200-662-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ACETONE
ChEMBL Phase
-1
Adverse Events
43
Bioactivity
4
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Acetone?
Acetone has 91 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
What regulatory lists include Acetone?
Acetone appears on 32 regulatory/inventory lists including air; detected; emissions; Europe; Other direct contact consumer goods, drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; non_food_use; Pesticides, and 29 more. Source: EPA CPDat.
What are the occupational exposure limits for Acetone?
Occupational exposure limits for Acetone are set by OSHA, NIOSH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Acetone used in cosmetics?
Yes, Acetone is also indexed as a cosmetic ingredient under the name Acetone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetone come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Acetone have different safety status in cosmetics vs industrial chemicals?
Acetone is classified GHS Danger (H225, H336, H319) in the chemicals database but is allowed in EU cosmetics.
Is Acetone used outside industrial chemicals?
Acetone also appears in cosmetics, pharmaceutical, cannabis databases.