What is the NOAEL for Sodium 4-methylbenzenesulfonate?
Sodium 4-methylbenzenesulfonate has 10 NOAEL studies in the database. The lowest reported value is 37.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium 4-methylbenzenesulfonate
Also known as: Sodium p-tolylsulfonate, EINECS 211-522-5, Naxonate hydrotrope, NSC 203318, para-Toluenesulfonic acid, sodium salt (+5 more)
CAS 657-84-1
Sodium 4-methylbenzenesulfonate (CAS 657-84-1) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Sodium 4-methylbenzenesulfonate is classified GHS Danger (H301, H312, H317, H319, H332, H341, H351, H400) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Sodium 4-methylbenzenesulfonate
CAS Number
657-84-1
DTXSID
DTXSID9042415
Molecular Formula
C7H8O3S.Na
InChI Key
KVCGISUBCHHTDD-UHFFFAOYSA-M
Synonyms
Sodium p-tolylsulfonateEINECS 211-522-5Naxonate hydrotropeNSC 203318para-Toluenesulfonic acid, sodium saltSodium paratoluene sulphonateSodium toluene-p-sulphonatep-Toluenesulfonic acid sodium saltTosylate, sodiumUNII-2V179P6Q43
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =37.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 2V179P6Q43 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2V179P6Q43 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2V179P6Q43 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2V179P6Q43 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >7000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium toluene-4-sulphonate | 211-522-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3186382
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Sodium 4-methylbenzenesulfonate?
Sodium 4-methylbenzenesulfonate appears on 1 regulatory/inventory list including inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is Sodium 4-methylbenzenesulfonate used in cosmetics?
Yes, Sodium 4-methylbenzenesulfonate is also indexed as a cosmetic ingredient under the name Sodium Toluenesulfonate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium 4-methylbenzenesulfonate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Sodium 4-methylbenzenesulfonate have different safety status in cosmetics vs industrial chemicals?
Sodium 4-methylbenzenesulfonate is classified GHS Danger (H301, H312, H317, H319, H332, H341, H351, H400) in the chemicals database but is allowed in EU cosmetics.
Is Sodium 4-methylbenzenesulfonate used outside industrial chemicals?
Sodium 4-methylbenzenesulfonate also appears in cosmetics, pharmaceutical databases.