What is the NOAEL for Orotic acid?
Orotic acid has 7 NOAEL studies in the database. The lowest reported value is 61H4T033E5 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Orotic acid
Also known as: EINECS 200-619-8, UNII-61H4T033E5, 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidecarboxylic acid, 1,2,3,6-Tetrahydro-2,6-dioxopyrimidin-4-carbonsaeure, 2,6-Dihydroxy-4-pyrimidinecarboxylic acid (+15 more)
CAS 65-86-1
Orotic acid (CAS 65-86-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Orotic acid
CAS Number
65-86-1
DTXSID
DTXSID0025814
Molecular Formula
C5H4N2O4
InChI Key
PXQPEWDEAKTCGB-UHFFFAOYSA-N
Monoisotopic Mass
156.017107
Synonyms
EINECS 200-619-8UNII-61H4T033E51,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidecarboxylic acid1,2,3,6-Tetrahydro-2,6-dioxopyrimidin-4-carbonsaeure2,6-Dihydroxy-4-pyrimidinecarboxylic acid2,6-Dihydroxypyrimidine-4-carboxylic acid2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid2,6-dioxo-3H-pyrimidine-4-carboxylic acid6-Carboxy-2,4-dihydroxypyrimidineAcidum oroticumLactiniumMolkensaeure
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 61H4T033E5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 61H4T033E5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 61H4T033E5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 61H4T033E5 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =50 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Orotic acid | 200-619-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OROTIC ACID
ChEMBL Phase
2
Adverse Events
0
Bioactivity
4
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Orotic acid?
Orotic acid appears on 3 regulatory/inventory lists including pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, Canada; pharmaceutical. Source: EPA CPDat.
Is Orotic acid used in cosmetics?
Yes, Orotic acid is also indexed as a cosmetic ingredient under the name OROTIC ACID. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Orotic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Orotic acid used outside industrial chemicals?
Orotic acid also appears in cosmetics, pharmaceutical, cannabis databases.