Danger GHS08GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

Benzoic acid

Also known as: Benzoesaeure GK, Benzoesaeure GV, Benzoic acid, tech., Caswell No. 081, EINECS 200-618-2 (+15 more)

CAS 65-85-0

Benzoic acid (CAS 65-85-0) is a chemical substance with GHS signal word Danger; key hazard signal: H372 (inhalation) (lungs); H315; H318. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Benzoic Acid →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
60
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Benzoic acid
CAS Number
65-85-0
DTXSID
DTXSID6020143
Molecular Formula
C7H6O2
InChI Key
WPYMKLBDIGXBTP-UHFFFAOYSA-N
Monoisotopic Mass
122.036779
Synonyms
Benzoesaeure GKBenzoesaeure GVBenzoic acid, tech.Caswell No. 081EINECS 200-618-2EPA Pesticide Chemical Code 009101FEMA No. 2131Flowers of benjaminFlowers of benzoinUnisept BZAKyselina benzoovaUNII-8SKN0B0MIM

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
STOT RE 1; Skin Irrit. 2; Eye Dam. 1H372 (inhalation) (lungs); H315; H318GHS08; GHS05Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordWARNING
GHS Hazard StatementsCauses serious eye damage May cause damage to lungs if inhaled Harmful to aquatic life
Short-term EffectsThe substance is severely irritating to the eyes. The substance is mildly irritating to the skin. Exposure could cause a non-allergic rash on contact.
Long-term EffectsLungs may be affected by repeated or prolongated exposure to an aerosol of this substance.
Routes of ExposureThe substance can be absorbed into the body by inhalation, by ingestion and through the skin.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
FragrancePreservativeDeodorizerFillerpH regulating agentFlavouring and nutrientPlasticizerNo specific technical functionAntioxidantProcessing aids not otherwise specified

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records
ListKeywordSource
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; agricultural; applied; PesticidesArizona Department of Environmental QualityState of Arizona
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
inert_ingredient; PesticidesEPACPCat
inert_ingredient; non_food_use; PesticidesEPACPCat
artificial_saliva; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - body hygiene - hand soapDanish Environmental Protection AgencyDanish EPA
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; fruits_and_vegetables; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; applied; legumes; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
4%-oralratUnifiedCodex:SCCNFP:beta.noael_studies
4%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
175mg/kg bw--ratUnifiedCodex:SCCNFP:beta.noael_studies
175mg/kg bw--ratUnifiedCodex:SCCNFP:beta.noael_studies
175mg/kg bw--ratUnifiedCodex:SCCNFP:beta.noael_studies
175mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
175mg/kg bw--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
250mg/kg bw--ratUnifiedCodex:SCCNFP:beta.noael_studies
250mg/kg bw--rabbitUnifiedCodex:SCCNFP:beta.noael_studies
250mg/kg bw--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
300mg/kg bw--ratUnifiedCodex:SCCNFP:beta.noael_studies
300mg/kg bw---UnifiedCodex:SCCNFP:beta.noael_studies
300mg/kg bw--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/d--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/d--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/d--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
1000mg/kg bw/d-intravenousratUnifiedCodex:SCCNFP:beta.noael_studies
=5mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=5mg/kg bw/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=20mg/kgADIoralHumanToxValDB_WHO_JECFA_ADI
=300mg/person/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=300mg/person/dayADI-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=5mg/kg bw/dayADI (group)-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=5mg/kg bw/dayADI (group)-ConsumersEFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
>854.861ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
1000ug/mLCV75Dermal-NTP_ICE_skin_sensitization
0.78uL/min/10^6 cellsClint-RatNTP_ICE_adme_parameters
=0.1mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
=3mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
16.2%Depletion CysDermal-NTP_ICE_skin_sensitization
22.6%Depletion CysDermal-NTP_ICE_skin_sensitization
23.4%Depletion LysDermal-NTP_ICE_skin_sensitization
68.1%Depletion LysDermal-NTP_ICE_skin_sensitization
23%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
42.2%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
>2000uMEC1.5Dermal-NTP_ICE_skin_sensitization
8SKN0B0MIMUNIIFDA UNII substance identifier--openFDA substances
8SKN0B0MIMUNIIFDA UNII substance identifier--openFDA substances
8SKN0B0MIMUNIIFDA UNII substance identifier--openFDA substances
8SKN0B0MIMUNIIFDA UNII substance identifier--openFDA substances
0.422fractionFu-RatNTP_ICE_adme_parameters
1.1ratioImaxDermal-NTP_ICE_skin_sensitization
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
1350ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
3750ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
>0.026mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=1700mg/kg bwLD50oralRatNTP_ICE_acute_oral
=2360mg/kg bwLD50oralRatNTP_ICE_acute_oral
=2565mg/kg bwLD50oralRatNTP_ICE_acute_oral

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredBenzoic acid200-618-2ECHA overview →

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.5%
Category
preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BENZOIC ACID
ChEMBL Phase
-1
Adverse Events
1
Bioactivity
11
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E210 — ADI: 5 mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Benzoic acid?

Benzoic acid (CAS 65-85-0) is classified under EU CLP Annex VI as STOT RE 1; Skin Irrit. 2; Eye Dam. 1 with signal word Danger. Hazard statements: H372 (inhalation) (lungs); H315; H318. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Benzoic acid?

Benzoic acid has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Benzoic acid?

Benzoic acid appears on 22 regulatory/inventory lists including active_ingredient; agricultural; applied; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, and 19 more. Source: EPA CPDat.

Is Benzoic acid used in cosmetics?

Yes, Benzoic acid is also indexed as a cosmetic ingredient under the name Benzoic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Benzoic acid come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Benzoic acid have different safety status in cosmetics vs industrial chemicals?

Benzoic acid is classified GHS Danger (H372, H315, H318) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

Is Benzoic acid used outside industrial chemicals?

Benzoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.