What is the NOAEL for 1-[4-(1-Methylethyl)phenyl]ethan-1-one?
1-[4-(1-Methylethyl)phenyl]ethan-1-one has 4 NOAEL studies in the database. The lowest reported value is 742ZKZ2A6D UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-[4-(1-Methylethyl)phenyl]ethan-1-one
Also known as: Acetophenone, 4'-isopropyl-, Acetylcumene, p-, Cuminone, EINECS 211-433-1, FEMA No. 2927 (+7 more)
CAS 645-13-6
1-[4-(1-Methylethyl)phenyl]ethan-1-one (CAS 645-13-6) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for P-ISOPROPYLPHENYL METHYL KETONE →
SOURCE
NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
5
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
18 fields
Name
1-[4-(1-Methylethyl)phenyl]ethan-1-one
CAS Number
645-13-6
DTXSID
DTXSID0052330
Molecular Formula
C11H14O
InChI Key
PDLCCNYKIIUWHA-UHFFFAOYSA-N
Monoisotopic Mass
162.104465
Synonyms
Acetophenone, 4'-isopropyl-Acetylcumene, p-CuminoneEINECS 211-433-1FEMA No. 2927p-Isopropylacetophenone4'-IsopropylacetophenoneIsopropylacetylbenzene, p-Methyl p-isopropylphenyl ketone1-(4-(1-Methylethyl)phenyl)ethanoneNSC 9165UNII-742ZKZ2A6D
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| pharmaceutical | US International Trade Commission | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 742ZKZ2A6D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 742ZKZ2A6D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 742ZKZ2A6D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 742ZKZ2A6D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1-[4-(1-methylethyl)phenyl]ethan-1-one | 211-433-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1-[4-(1-Methylethyl)phenyl]ethan-1-one?
1-[4-(1-Methylethyl)phenyl]ethan-1-one appears on 5 regulatory/inventory lists including Europe, pharmaceutical, IFRA Transparency, and 2 more. Source: EPA CPDat.
Is 1-[4-(1-Methylethyl)phenyl]ethan-1-one used in cosmetics?
Yes, 1-[4-(1-Methylethyl)phenyl]ethan-1-one is also indexed as a cosmetic ingredient under the name P-ISOPROPYLPHENYL METHYL KETONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-[4-(1-Methylethyl)phenyl]ethan-1-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1-[4-(1-Methylethyl)phenyl]ethan-1-one used outside industrial chemicals?
1-[4-(1-Methylethyl)phenyl]ethan-1-one also appears in cosmetics, food safety, cannabis databases.