What is the GHS hazard classification for Acetic acid?
Acetic acid (CAS 64-19-7) is classified under EU CLP Annex VI as Flam. Liq. 3; Skin Corr. 1A with signal word Danger. Hazard statements: H226; H314. Source: EU CLP Annex VI (ECHA).
Danger
GHS02GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Acetic acid
Also known as: Vinegar, 4-02-00-00094, BRN 0506007, Caswell No. 003, EINECS 200-580-7 (+15 more)
CAS 64-19-7
Acetic acid (CAS 64-19-7) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H314. Key regulatory status: REACH registered, 56 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC, OSHA.
View cosmetic safety profile for Acetic Acid — Deep Research Profile →
Cross-Vertical Regulatory Divergence
Acetic acid is classified GHS Danger (H226, H314) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
55
SOURCE
chemical inventory jurisdictions
Regulatory lists
56
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
26 fields
Name
Acetic acid
CAS Number
64-19-7
DTXSID
DTXSID5024394
Molecular Formula
C2H4O2
InChI Key
QTBSBXVTEAMEQO-UHFFFAOYSA-N
Monoisotopic Mass
60.021129
Synonyms
Vinegar4-02-00-00094BRN 0506007Caswell No. 003EINECS 200-580-7EPA Pesticide Chemical Code 044001FEMA No. 2006FEMA Number 2006Pyroligneous acidAcetic acid 0.25% in plastic containerAcido aceticoAzijnzuur
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Skin Corr. 1A | H226; H314 | GHS02; GHS05 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Flammable liquid and vapour Harmful in contact with skin or if inhaled May be harmful if swallowed Causes severe skin burns and eye damage May cause respiratory irritation Causes damage to the respiratory tract through prolonged or repeated exposure if inhaled Harmful to aquatic life |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. Lungs may be affected by repeated or prolongated exposure to an aerosol of this substance. Risk of tooth erosion upon repeated or prolongated exposure to an aerosol of this substance. |
| Routes of Exposure | Serious local effects by all routes of exposure. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
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OSHA / NIOSH / ACGIH occupational exposure limits
10 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 10 ppm (25 mg/m³) | 10 | 25 | N |
| NIOSH | TWA | 10 ppm (25 mg/m³) | 10 | 25 | N |
| NIOSH | STEL | 15 ppm (37 mg/m³) | 15 | 37 | N |
| CAL/OSHA | TWA | 10 ppm (25 mg/m³) | 10 | 25 | N |
| CAL/OSHA | STEL | 15 ppm (37 mg/m³) | 15 | 37 | N |
| CAL/OSHA | CEILING | 40 ppm | 40 | - | N |
| NIOSH | IDLH | 50 ppm | 50 | - | - |
| AIHA | ERPG-1 | 5 ppm | 5 | - | - |
| AIHA | ERPG-2 | 35 ppm | 35 | - | - |
| AIHA | ERPG-3 | 250 ppm | 250 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
60 records
pH regulating agentDeodorizerFragranceFlavouring and nutrientNo specific technical functionDegradant/impurityChelating agentProcessing aids not otherwise specifiedCleaning agentSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
56 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; grain; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; legumes; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; grain; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; grain; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; fruits_and_vegetables; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; applied; grain; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 50 of 55 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 21.7 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| 28.5 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| 35 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| =25 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 68 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| Q40Q9N063P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q40Q9N063P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q40Q9N063P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q40Q9N063P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 1 | unitless | GHS classification | Dermal | Rabbit | NTP_ICE_skin_irritation |
| - | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| 11 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =98245.1 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =0.00001 | mM | LOEL | environmental | European Rabbit | ToxValDB_ECOTOX |
| =0.1 | % | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =0.667 | mmol | LOEL | dermal | Mouse | ToxValDB_ECOTOX |
| =2 | mL/kg | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =3 | % | LOEL | environmental | Rat | ToxValDB_ECOTOX |
| =3 | % w/v | LOEL | dermal | European Rabbit | ToxValDB_ECOTOX |
| =5 | % | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =10 | % | LOEL | dermal | Rat | ToxValDB_ECOTOX |
| =10 | mL/kg | LOEL | injection | Rat | ToxValDB_ECOTOX |
| =10 | % w/v | LOEL | dermal | European Rabbit | ToxValDB_ECOTOX |
| =40 | mg | LOEL | dermal | Mouse | ToxValDB_ECOTOX |
| =75 | uL | LOEL | dermal | Rat | ToxValDB_ECOTOX |
| =100 | % | LOEL | dermal | Rat | ToxValDB_ECOTOX |
| =122.806 | mg/m3 | LOEL | inhalation | Human | ToxValDB_NIOSH_IDLH |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =10 | mg/m3 | NOAEC | inhalation | Human | ToxValDB_EFSA |
| =16 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_EFSA |
| =16 | mg/kg bw/day | NOAEL | oral: unspecified | Rabbit | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 390 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 400 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 700 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| >=1600 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =0.3 | mL/L | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =3 | % w/v | NOEL | dermal | European Rabbit | ToxValDB_ECOTOX |
| =10 | % w/v | NOEL | dermal | European Rabbit | ToxValDB_ECOTOX |
| =20 | mg | NOEL | dermal | Mouse | ToxValDB_ECOTOX |
| 51 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 9.5 | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 32.6 | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 1.3 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 1.5 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 2.6 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.8 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 3 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 2.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 50 of 55 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Acetic acid | 200-580-7 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ACETIC ACID
ChEMBL Phase
4
Adverse Events
41
Bioactivity
7
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E260 — ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Acetic acid?
Acetic acid has 55 NOAEL studies in the database. The lowest reported value is 0 %/sec via Ocular. Source: NTP_ICE_eye_irritation.
What regulatory lists include Acetic acid?
Acetic acid appears on 29 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, and 26 more. Source: EPA CPDat.
What are the occupational exposure limits for Acetic acid?
Occupational exposure limits for Acetic acid are set by OSHA, NIOSH, CAL/OSHA. 10 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Acetic acid used in cosmetics?
Yes, Acetic acid is also indexed as a cosmetic ingredient under the name Acetic Acid — Deep Research Profile. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Acetic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Acetic acid have different safety status in cosmetics vs industrial chemicals?
Acetic acid is classified GHS Danger (H226, H314) in the chemicals database but is allowed in EU cosmetics.
Is Acetic acid used outside industrial chemicals?
Acetic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.