Also known as: EDTA, tetrasodium salt, Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, tetrasodium salt, Aquamoline BC, Caswell No. 846, Cheelox BF-12 (+15 more)
CAS 64-02-8
Ethylenediaminetetraacetic acid tetrasodium salt (CAS 64-02-8) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H318. Key regulatory status: REACH registered, 43 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
Ethylenediaminetetraacetic acid tetrasodium salt is classified GHS Danger (H302, H318) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Eye Dam. 1 | H302; H318 | GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Harmful if swallowed Causes mild skin irritation Causes serious eye irritation |
| Short-term Effects | The substance is irritating to the eyes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| MP1J8420LU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| MP1J8420LU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| MP1J8420LU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| MP1J8420LU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 130 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1374 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 7 of 7 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tetrasodium ethylenediaminetetraacetate | 200-573-9 | ECHA overview → |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Ethylenediaminetetraacetic acid tetrasodium salt (CAS 64-02-8) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Dam. 1 with signal word Danger. Hazard statements: H302; H318. Source: EU CLP Annex VI (ECHA).
Ethylenediaminetetraacetic acid tetrasodium salt has 7 NOAEL studies in the database. The lowest reported value is 1.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Ethylenediaminetetraacetic acid tetrasodium salt appears on 16 regulatory/inventory lists including Canada; pharmaceutical, Europe; Specialty occupational products, inert_ingredient; non_food_use; Pesticides, and 13 more. Source: EPA CPDat.
Yes, Ethylenediaminetetraacetic acid tetrasodium salt is also indexed as a cosmetic ingredient under the name Tetrasodium EDTA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Ethylenediaminetetraacetic acid tetrasodium salt is classified GHS Danger (H302, H318) in the chemicals database but is allowed in EU cosmetics.
Ethylenediaminetetraacetic acid tetrasodium salt also appears in cosmetics, pharmaceutical, food safety databases.