What is the NOAEL for S-(Carboxymethyl)-L-cysteine?
S-(Carboxymethyl)-L-cysteine has 5 NOAEL studies in the database. The lowest reported value is 740J2QX53R UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
S-(Carboxymethyl)-L-cysteine
Also known as: S-Carbocysteine, (R)-S-(Carboxymethyl)cysteine, (L)-2-Amino-3-(carboxymethylthio)propionic acid, BRN 1725012, S-Carboxylmethyl-L-cysteine (+15 more)
CAS 638-23-3
S-(Carboxymethyl)-L-cysteine (CAS 638-23-3) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
S-(Carboxymethyl)-L-cysteine is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
S-(Carboxymethyl)-L-cysteine
CAS Number
638-23-3
DTXSID
DTXSID30110060
Molecular Formula
C5H9NO4S
InChI Key
GBFLZEXEOZUWRN-VKHMYHEASA-N
Monoisotopic Mass
179.025229
Synonyms
S-Carbocysteine(R)-S-(Carboxymethyl)cysteine(L)-2-Amino-3-(carboxymethylthio)propionic acidBRN 1725012S-Carboxylmethyl-L-cysteine3-(Carboxymethylthio)-L-alanineEINECS 211-327-5MuciclarMucocisMucodyneNSC 14156Reomucil
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Softener and conditionerPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 740J2QX53R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 740J2QX53R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 740J2QX53R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 740J2QX53R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >15000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CARBOCYSTEINE
ChEMBL Phase
3
Adverse Events
1093
Bioactivity
2
Frequently Asked Questions
What regulatory lists include S-(Carboxymethyl)-L-cysteine?
S-(Carboxymethyl)-L-cysteine appears on 3 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is S-(Carboxymethyl)-L-cysteine used in cosmetics?
Yes, S-(Carboxymethyl)-L-cysteine is also indexed as a cosmetic ingredient under the name Carbocysteine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for S-(Carboxymethyl)-L-cysteine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does S-(Carboxymethyl)-L-cysteine have different safety status in cosmetics vs industrial chemicals?
S-(Carboxymethyl)-L-cysteine is classified GHS Danger (H314) in the chemicals database but is allowed in EU cosmetics.
Is S-(Carboxymethyl)-L-cysteine used outside industrial chemicals?
S-(Carboxymethyl)-L-cysteine also appears in cosmetics, pharmaceutical databases.