NOAEL Data REACH Registered Cosmetic Ingredient

C.I. Acid Orange 7

Also known as: Acid Orange II, EC No.: 211-199-0, Benzenesulfonic acid, p-(2-hydroxy-1-naphthylazo)-, sodium salt, D&C Orange 4, Acid Leather Orange Extra (+14 more)

CAS 633-96-5

C.I. Acid Orange 7 (CAS 633-96-5) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Orange 4 (CI 15510) →

SOURCE noael studies public
NOAEL studies
84
SOURCE chemical inventory jurisdictions
Regulatory lists
12
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields
Name
C.I. Acid Orange 7
CAS Number
633-96-5
DTXSID
DTXSID0038881
Molecular Formula
C16H12N2O4S.Na
InChI Key
CQPFMGBJSMSXLP-UHFFFAOYSA-M
Synonyms
Acid Orange IIEC No.: 211-199-0Benzenesulfonic acid, p-(2-hydroxy-1-naphthylazo)-, sodium saltD&C Orange 4Acid Leather Orange ExtraAcid Leather Orange Extra GAcid Leather Orange Extra PRWAcid Leather Orange PRWEINECS 211-199-0p-((2-Hydroxy-1-naphthyl)azo)benzenesulfonic acid sodium salt4-((2-Hydroxy-1-naphthyl)azo)benzenesulfonic acid, sodium saltKayaku Acid Orange II

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 53 records
DyeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records
ListKeywordSource
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
inert_ingredient; non_food_use; PesticidesEPACPCat
IFRA TransparencyIFRAIFRA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal care - hair styling and care - shampooDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
Personal careFDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 84 studies
ValueUnitEndpointRouteSpeciesSource
2.5mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2.5mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2.5mg/kg bw/ day-dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
2.5mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
2.5mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2.5mg/kg bw/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2.5mg/kg bw/ day-dermalrabbitUnifiedCodex:SCCS_SHADOW:beta.noael_studies
2.5mg/kg bw/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
5mg/kg-oralratUnifiedCodex:SCCNFP:beta.noael_studies
5mg/kg bw/day--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
5mg/kg bw/day--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.176mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
Q1LIY3BO0UUNIIFDA UNII substance identifier--openFDA substances
Q1LIY3BO0UUNIIFDA UNII substance identifier--openFDA substances
Q1LIY3BO0UUNIIFDA UNII substance identifier--openFDA substances
Q1LIY3BO0UUNIIFDA UNII substance identifier--openFDA substances
=5mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
=100mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
-unitlessModel Score--NTP_ICE_endocrine
=0.83mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.83mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.83mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.83mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.5mg/kg bw/dayNOAEL--SCCS_vision_codex
=2.5mg/kg bw/ dayNOAELdermalrabbitSCCS_vision_codex
=2.5mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.5mg/kg bw/dayNOAEL--SCCS_vision_codex
=2.5mg/kg bw/ dayNOAELdermalrabbitSCCS_vision_codex
=2.5mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.5mg/kgNOAELdermalrabbitSCCNFP_vision_codex
=2.5mg/kg bw/dayNOAEL--SCCS_vision_codex
=2.5mg/kg bw/ dayNOAELdermalrabbitSCCS_vision_codex
=2.5mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.5mg/kg bw/dayNOAEL--SCCS_vision_codex
=2.5mg/kg bw/ dayNOAELdermalrabbitSCCS_vision_codex
=2.5mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.5mg/kg bw/dayNOAEL--SCCS_vision_codex
=2.5mg/kg bw/ dayNOAELdermalrabbitSCCS_vision_codex
=2.5mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.5mg/kg bw/dayNOAEL--SCCS_vision_codex
=2.5mg/kg bw/ dayNOAELdermalrabbitSCCS_vision_codex
=2.5mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.5mg/kgNOAELdermalrabbitSCCNFP_vision_codex
=2.5mg/kgNOAELdermalrabbitSCCNFP_vision_codex
=2.5mg/kg bw/dayNOAEL--SCCS_vision_codex
=2.5mg/kg bw/ dayNOAELdermalrabbitSCCS_vision_codex
=2.5mg/kg bw/dNOAELoralratSCCS_vision_codex
=2.5mg/kg bw/dayNOAEL--SCCS_vision_codex
=2.5mg/kg bw/ dayNOAELdermalrabbitSCCS_vision_codex
=2.5mg/kg bw/dNOAELoralratSCCS_vision_codex

Showing 50 of 84 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredSodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate211-199-0ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1536/1423 September 2014safe0.5%moderate sensitiser
SCCS/1437/1122 March 2011safe0.5%sensitisation potential not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL2028473
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E111 — ADI: DECISION POSTPONED mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for C.I. Acid Orange 7?

C.I. Acid Orange 7 has 84 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include C.I. Acid Orange 7?

C.I. Acid Orange 7 appears on 8 regulatory/inventory lists including Europe; Personal care - hair coloring, inert_ingredient; non_food_use; Pesticides, IFRA Transparency, and 5 more. Source: EPA CPDat.

Is C.I. Acid Orange 7 used in cosmetics?

Yes, C.I. Acid Orange 7 is also indexed as a cosmetic ingredient under the name Orange 4 (CI 15510). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Acid Orange 7 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is C.I. Acid Orange 7 used outside industrial chemicals?

C.I. Acid Orange 7 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.