What is the NOAEL for L-Methionine?
L-Methionine has 22 NOAEL studies in the database. The lowest reported value is 110.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Methionine
Also known as: 2-Amino-4-methylthiobutanoic acid (S)-, 2-Amino-4-(methylthio)butyric acid, (S)-, EINECS 200-562-9, Methioninum, UNII-AE28F7PNPL (+15 more)
CAS 63-68-3
L-Methionine (CAS 63-68-3) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
22
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Methionine
CAS Number
63-68-3
DTXSID
DTXSID5040548
Molecular Formula
C5H11NO2S
InChI Key
FFEARJCKVFRZRR-BYPYZUCNSA-N
Monoisotopic Mass
149.05105
Synonyms
2-Amino-4-methylthiobutanoic acid (S)-2-Amino-4-(methylthio)butyric acid, (S)-EINECS 200-562-9MethioninumUNII-AE28F7PNPL(2S)-2-amino-4-(methylsulfanyl)butanoate(2S)-2-amino-4-(methylsulfanyl)butanoic acid(2S)-2-amino-4-methylsulfanyl-butanoic acid(L)-methionine(S)-(+)-methionine(S)-2-Amino-4-(methylthio)butanoate(S)-2-amino-4-(methylthio)-Butanoate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Flavouring and nutrientSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =110.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| AE28F7PNPL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AE28F7PNPL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AE28F7PNPL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AE28F7PNPL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =36000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >6600 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 5.71 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 224 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 250 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1200 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 1400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1476 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS_DB |
| 1490 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1700 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1722 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | L-methionine | 200-562-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
amino_acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
METHIONINE
ChEMBL Phase
3
Adverse Events
104
Bioactivity
4
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Methionine?
L-Methionine appears on 6 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Europe, and 3 more. Source: EPA CPDat.
Is L-Methionine used in cosmetics?
Yes, L-Methionine is also indexed as a cosmetic ingredient under the name L-Methionine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Methionine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Methionine used outside industrial chemicals?
L-Methionine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.